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Abstract: PO1127

A Polyethersulfone Membrane with a Direct Thrombin Inhibitor to Decrease Local Thrombus Formation

Session Information

Category: Dialysis

  • 701 Dialysis: Hemodialysis and Frequent Dialysis

Authors

  • Fu, Shuangshuang, Nephrology Department of Hunan Provincial People’s Hospital (The First-affiliated Hospital of Hunan Normal University), Changsha, Hunan, China
  • Liang, Yumei, Nephrology Department of Hunan Provincial People’s Hospital (The First-affiliated Hospital of Hunan Normal University), Changsha, Hunan, China
Background

Extracorporeal circulation, such as hemodialysis, is required systemic anticoagulation to avoid thrombus formation. However, conventional anticoagulation methods may induce hemorrhage complications, especially those patients who have bleeding diseases. As dialyzer membrane is the main site of thrombosis. Anticoagulant modification of the dialysis membrane may decrease local clotting of the dialyzer membrane, and doesn't increase the bleeding risk of dialysis patients.

Methods

We chose argatroban(AG), a direct thrombin inhibitor, to modify a polyethersulfone(PES) membrane. Fourier transform infrared spectroscopy(FTIR) was used to confirm that AG was grafted to the PES successfully. Scanning electron microscopy(SEM) was used to observe the characteristic morphology of the membranes. Activated partial thromboplastin time, prothrombin time, and thrombin time were detected to evaluate the antithrombotic property of the modified membrane.

Results

FTIR indicated that argatroban modified PES membranes(PES-AG) were successfully prepared. Compared with the PES membrane, the clotting time value of the PES-AG membrane was significantly prolonged, and the difference was statistically significant, which initially indicated that the PES-AG membrane had a better anticoagulant effect. SEM showed that the PES-AG membrane could decrease local thrombus formation.

Conclusion

Preparation of the argatroban modified PES membrane is feasible, and the anticoagulant performance is superior to the unmodified PES membrane.

FTIR of PES and modified membranes

the surface local thrombus formation SEM micrographs of PES and modified
membranes

Funding

  • Government Support - Non-U.S.