Abstract: PO1127
A Polyethersulfone Membrane with a Direct Thrombin Inhibitor to Decrease Local Thrombus Formation
Session Information
- Hemodialysis and Frequent Dialysis - 2
October 22, 2020 | Location: On-Demand
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 701 Dialysis: Hemodialysis and Frequent Dialysis
Authors
- Fu, Shuangshuang, Nephrology Department of Hunan Provincial People’s Hospital (The First-affiliated Hospital of Hunan Normal University), Changsha, Hunan, China
- Liang, Yumei, Nephrology Department of Hunan Provincial People’s Hospital (The First-affiliated Hospital of Hunan Normal University), Changsha, Hunan, China
Background
Extracorporeal circulation, such as hemodialysis, is required systemic anticoagulation to avoid thrombus formation. However, conventional anticoagulation methods may induce hemorrhage complications, especially those patients who have bleeding diseases. As dialyzer membrane is the main site of thrombosis. Anticoagulant modification of the dialysis membrane may decrease local clotting of the dialyzer membrane, and doesn't increase the bleeding risk of dialysis patients.
Methods
We chose argatroban(AG), a direct thrombin inhibitor, to modify a polyethersulfone(PES) membrane. Fourier transform infrared spectroscopy(FTIR) was used to confirm that AG was grafted to the PES successfully. Scanning electron microscopy(SEM) was used to observe the characteristic morphology of the membranes. Activated partial thromboplastin time, prothrombin time, and thrombin time were detected to evaluate the antithrombotic property of the modified membrane.
Results
FTIR indicated that argatroban modified PES membranes(PES-AG) were successfully prepared. Compared with the PES membrane, the clotting time value of the PES-AG membrane was significantly prolonged, and the difference was statistically significant, which initially indicated that the PES-AG membrane had a better anticoagulant effect. SEM showed that the PES-AG membrane could decrease local thrombus formation.
Conclusion
Preparation of the argatroban modified PES membrane is feasible, and the anticoagulant performance is superior to the unmodified PES membrane.
FTIR of PES and modified membranes
the surface local thrombus formation SEM micrographs of PES and modified
membranes
Funding
- Government Support - Non-U.S.