ASN's Mission

ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005


The Latest on Twitter

Kidney Week

Abstract: PO0013

Incidence and Impact of AKI on Patients with Implantable Left Ventricular Assist Devices: A Meta-Analysis

Session Information

Category: Acute Kidney Injury

  • 101 AKI: Epidemiology, Risk Factors, and Prevention


  • Thongprayoon, Charat, Mayo Clinic Minnesota, Rochester, Minnesota, United States
  • Cheungpasitporn, Wisit, University of Mississippi Medical Center, Jackson, Mississippi, United States
  • Hansrivijit, Panupong, UPMC Pinnacle, Harrisburg, Pennsylvania, United States
  • Fulop, Tibor, Medical University of South Carolina, Charleston, South Carolina, United States
  • Kanduri, Swetha Rani, University of Mississippi Medical Center, Jackson, Mississippi, United States
  • Mao, Michael A., Mayo Clinic's Campus in Florida, Jacksonville, Florida, United States
  • Kashani, Kianoush, Mayo Clinic Minnesota, Rochester, Minnesota, United States

This systematic review and meta-analysis was performed to evaluate the acute kidney injury (AKI) incidence and its associated risk of mortality in patients with implantable left ventricular assist devices (LVAD).


A systematic literature search in MEDLINE, EMBASE, and Cochrane Databases was conducted through January 2020 to identify studies that provided data on the AKI incidence, and AKI-associated mortality risk in adult patients with implantable LVADs. Pooled effect estimates were examined using random-effects, generic inverse variance method of DerSimonian-Laird.


56 cohort studies with 63,663 LVAD patients were enrolled in this meta-analysis of AKI incidence. The pooled incidence of reported AKI was 24.9% (95%CI: 20.1%-30.4%), but rose to 36.9% (95%CI: 31.1%-43.1%) when applying the standard definition of AKI per RIFLE, AKIN, and KDIGO criteria. The pooled incidence of severe AKI requiring renal replacement therapy (RRT) was 12.6% (95%CI: 10.5%-15.0%). AKI incidence did not differ significantly between types of LVAD (p = 0.35) or indication for LVAD use (p = 0.62). While meta-regression analysis did not demonstrate a significant association between study year and overall AKI incidence (P=0.55), the study year was negatively correlated with incidence of severe AKI requiring RRT (slope = -0.068, p <0.001). The pooled odds ratios (ORs) of mortality at 30 days and 1 year in AKI patients were 3.66 (95% CI, 2.00-6.70) and 2.22 (95% CI, 1.62-3.04), respectively. The pooled ORs of mortality at 30 day and 1 year in severe AKI patients requiring RRT were 7.52 (95% CI, 4.58-12.33) and 5.41 (95% CI, 3.63-8.06), respectively.


37% of LVAD patients developed AKI based on standard definitions and 13% developed severe AKI requiring RRT. There has been potential improvement in the incidence of severe AKI requiring RRT for LVAD patients. AKI in LVAD patients was associated with increased 30-day and 1-year mortality.