Abstract: PO0586
A Pilot and Feasibility Randomized Clinical Trial Targeting Sedentary Behavior in CKD: Sit Less, Interact and Move More (SLIMM) Study
Session Information
- CKD Clinical, Outcomes, and Trials - 2
October 22, 2020 | Location: On-Demand
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2102 CKD (Non-Dialysis): Clinical, Outcomes, and Trials
Authors
- Boucher, Robert E., Division of Nephrology & Hypertension, University of Utah School of Medicine, Salt Lake City, Utah, United States
- Wei, Guo, Division of Nephrology & Hypertension, University of Utah School of Medicine, Salt Lake City, Utah, United States
- Greene, Tom, Division of Biostatistics, University of Utah School of Medicine, Salt Lake City, Utah, United States
- Beddhu, Srinivasan, Division of Nephrology & Hypertension, University of Utah School of Medicine, Salt Lake City, Utah, United States
Background
Sedentary behavior (engaging in activities in the seated/ lying position) is highly prevalent and associated with mortality in CKD.
Methods
In a 24-week pilot and feasibility RCT, we tested the feasibility of a ‘Sit Less, Interact, Move More (SLIMM)’ intervention to replace sedentary activities with casual stepping activities in CKD. Participants wore an accelerometer for 7 days before randomization to measure baseline sedentary and stepping durations. In the SLIMM group (N=54), these data were used to develop individualized plans targeting sedentary behavior; accelerometry was repeated every 4 weeks to monitor adherence and to provide personalized feedback. The standard of care (SOC) group (N=52) were provided physical activity guidelines and underwent folloow-up accelerometry at weeks 8, 16 and 24.
Results
Mean age was 69 ±13 yrs, 42% were women. 5%, 38%, 43% and 14% had CKD stages 2, 3A, 3B/4 and ESKD, respectively. Sedentary and stepping durations did not change in the SOC group. In the SLIMM group, the maximum decrease in sedentary duration, increase in stepping duration, and the number of steps/day, were seen at week 20 but attenuated at week 24 (Fig1). In separate linear mixed effects models (Table 1), overall treatment effects of the intervention on sedentary duration, stepping duration and the number of steps were not significant. The SLIMM intervention significantly reduced BMI and body fat%.
Conclusion
It is feasible to reduce sedentary duration and increase stepping duration in CKD but additional measures along with SLIMM intervention may be needed to sustain its effect on sedentary behavior.
Mixed effects models of treatment effects in SLIMM vs. Stand of Care groups
| Mean change (95% CI) | p-value | |
| Sedentary duration, min/d | -15.6 (-41.0, 9.6) | 0.22 |
| Stepping duration, min/d | 6.5 (-2.7, 15.6) | 0.16 |
| Number of steps/d | 631 (-166, 1429) | 0.12 |
| Body mass index, kg/m2 | -1.09 (-1.92, -0.26) | 0.010 |
| Body fat, % | -2.29 (-4.44, -0.14) | 0.038 |
Least square means estimates of sedentary and stepping durations and the number of steps/day by intervention group
Funding
- NIDDK Support