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Kidney Week

Abstract: PO1702

Modestly Low eGFR Is Not Associated with Cognitive Decline in the Elderly

Session Information

Category: Geriatric Nephrology

  • 1100 Geriatric Nephrology

Authors

  • Grasing, Michael, University of Kansas School of Medicine, Kansas City, Kansas, United States
  • Kennedy, Kevin, Kansas City VA Medical Center, Kansas City, Missouri, United States
  • Burns, Jeffrey M., University of Kansas Medical Center, Kansas City, Kansas, United States
  • Sarnak, Mark J., Tufts Medical Center, Boston, Massachusetts, United States
  • Gupta, Aditi, University of Kansas Medical Center, Kansas City, Kansas, United States
Background

Kidney disease is associated with cognitive impairment. Whether mild to moderate CKD is associated with cognitive decline in older adults is not clear. We evaluated changes in cognition in relation to baseline eGFR in the elderly Alzheimer’s Disease Neuroimaging Initiative (ADNI) participants.

Methods

ADNI is an NIH funded, multicenter study, which includes participants with normal and impaired cognition who were administered a comprehensive battery of neuropsychological tests every six months. We related the CKD-epi eGFR with previously validated composite scores for memory (ADNI-Mem) and executive function (ADNI-EF) in multivariable linear regression analysis.

Results

1127 participants with a mean age of 73.8±7.1 years, 57% men, 97% Caucasian, and mean follow up for 6±2.6 years were included. Mean baseline eGFR was 76.4±19 ml/min/1.73 m2. ADNI-Mem and ADNI-EF scores declined across all eGFR categories (figure). Older age and lower education were associated with declines in both ADNI-Mem and ADNI-EF scores. Baseline eGFR was not associated with declines in either ADNI-Mem or ADNI-EF scores (table).

Conclusion

There is no association between baseline eGFR and cognitive decline in elderly persons with mild-moderate impairment in kidney function.

Multivariable linear regression model for ADNI-Mem score and ADNI-EF score
 Beta estimate for
decline in ADNI-
Mem score
95% CIp valueBeta estimate for
decline in ADNI-
EF score
95% CIp value
Age (+10)-0.12-0.20, -0.030.006-0.28-0.37, -0.19<0.0001
Female sex0.310.18, 0.44<0.00010.14-0.01, 0.280.07
Caucasian race-0.12-0.36, 0.110.290.15-0.10, 0.40.24
Years of education (+1)0.080.06, 0.10<0.00010.100.08, 0.12<0.0001
eGFR (+10)-0.03-0.06, 0.010.110.004-0.03, 0.040.84

Change in ADNI-Mem and ANDI-EF scores by eGFR categories.

Funding

  • Other NIH Support