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Kidney Week

Abstract: PO0762

Incidence of COVID-19 Disease in Pediatric Kidney Transplant Recipients: A Report of the Improving Renal Outcomes Collaborative

Session Information

Category: Coronavirus (COVID-19)

  • 000 Coronavirus (COVID-19)

Authors

  • Varnell, Charles D., Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States
  • Al-Akash, Samhar I., Driscoll Children's Hospital, Corpus Christi, Texas, United States
  • Belsha, Craig W., SSM Health Cardinal Glennon Children's Hospital, Saint Louis, Missouri, United States
  • Chaudhuri, Abanti, Lucile Salter Packard Children's Hospital at Stanford, Palo Alto, California, United States
  • Engen, Rachel M., Ann and Robert H Lurie Children's Hospital of Chicago, Chicago, Illinois, United States
  • Fadakar, Paul, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania, United States
  • Garro, Rouba, Children's Healthcare of Atlanta Inc, Atlanta, Georgia, United States
  • Gluck, Caroline A., Alfred I DuPont Hospital for Children, Wilmington, Delaware, United States
  • Goebel, Jens W., Children's Hospital Colorado, Aurora, Colorado, United States
  • Misurac, Jason, The University of Iowa Stead Family Children's Hospital, Iowa City, Iowa, United States
  • Nailescu, Corina, Riley Hospital for Children at Indiana University Health, Indianapolis, Indiana, United States
  • Patel, Hiren P., Nationwide Children's Hospital, Columbus, Ohio, United States
  • Pruette, Cozumel S., Johns Hopkins University School of Medicine, Baltimore, Maryland, United States
  • Rodig, Nancy MacDonald, Boston Children's Hospital, Boston, Massachusetts, United States
  • Smith, Jodi M., Seattle Children's Hospital, Seattle, Washington, United States
  • VanSickle, Judith Sebestyen, Children's Mercy Hospitals and Clinics, Kansas City, Missouri, United States
  • Weng, Patricia L., Mattel Children's Hospital UCLA, Los Angeles, California, United States
  • Danziger-Isakov, Lara, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States
  • Hooper, David K., Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States
  • Seifert, Michael E., Benjamin Russell Hospital for Children, Birmingham, Alabama, United States

Group or Team Name

  • Improving Renal Outcomes Collaborative
Background

The impact of COVID-19 disease on previously healthy children has been minimal, yet there is limited data on the impact of COVID-19 on children and adolescents with kidney transplants.

Methods

We used the existing infrastructure of the Improving Renal Outcomes Collaborative (IROC) learning health system to develop and rapidly implement a web-based registry for collecting clinical and outcomes data about COVID-19 disease in pediatric transplant recipients. We distributed the registry to 32 U.S. pediatric kidney transplant centers and requested clinical and outcomes data from all recipients suspected of having COVID-19 disease. Here, we present an interim analysis of the first 6 weeks of registry data.

Results

Between April 6 and May 27, 2020, 18 IROC centers entered data on 99 pediatric kidney transplant recipients who had PCR based testing for COVID-19. 54 patients were tested due to symptoms of COVID-19 (most commonly fever and cough), 7 asymptomatic patients had a known COVID exposure. 34 patients were tested per hospital policy (e.g. pre-anesthesia), and 4 did not have a reported testing indication. Overall, 10/99 (10%) tested positive for COVID-19, 6 of whom had any symptoms, 3 had a known exposure with a COVID+ individual, and 1 was diagosed by a pre-anesthesia screen. Thus far, the clinical course and outcomes are known in 8/10 COVID-19+ patients: 5 received outpatient supportive care alone, 2 were admitted to intensive care and 1 was admitted to a non-intensive care inpatient unit. Transplant outcomes were excellent in all COVID-19+ patients. There were no cases with respiratory failure, acute kidney injury, or allograft rejection/failure. There were no deaths due to COVID-19 disease.

Conclusion

In this interim analysis of the IROC learning health system, pediatric kidney transplant recipients had a relatively low incidence of COVID-19 disease and excellent short-term outcomes.