Abstract: PO1452
Epidemiology of Hyperkalemia Among Patients Presenting at the Emergency Department in China
Session Information
- Fluid, Electrolyte, and Acid-Base Disorders: Clinical - 1
October 22, 2020 | Location: On-Demand
Abstract Time: 10:00 AM - 12:00 PM
Category: Fluid, Electrolyte, and Acid-Base Disorders
- 902 Fluid, Electrolyte, and Acid-Base Disorders: Clinical
Authors
- Bian, Jianming, Department of Pharmacology, Chinese People’s Liberation Army General Hospital, Beijing, China
- Zuo, Li, Department of Pharmacology, Chinese People’s Liberation Army General Hospital, Beijing, China
- Zhao, Houyu, Department of Pharmacology, Chinese People’s Liberation Army General Hospital, Beijing, China
- Han, Xu, Department of Pharmacology, Chinese People’s Liberation Army General Hospital, Beijing, China
Background
In China, the clinical burden of hyperkalemia (HK) among patients presenting emergency department (ED) is not well described.
Methods
Data containing hospital information system (HIS) records of 157 hospitals, covering 30 provinces in China were extracted from Beijing Data Center for Rational Use of Drugs. Patients presenting ED (aged >=18 years old) with record(s) of serum potassium (S-K) from 2015.1.1 to 2017.12.31 were included. Hyperkalemia were defined as S-K > 5.0 mmol/L. The proportion of patients experience at least one hyperkalemia and the severity of hyperkalemia were calculated among overall outpatients and patients with chronic kidney disease (CKD), heart failure (HF), hypertension (HTN), and diabetes mellitus (DM). The geographic and seasonal distribution of the proportion among overall patients were calculated.
Results
A total of 1,039,245 patients with at least one S-K record each were analysed, in which 36615 (3.52%) patients experienced HK (S-K >5.0 mmol/L), 15059 (1.45%) patients experienced S-K ≥5.5mmol/L. Analysing the index S-K in HK patients, the composition of patients with S-K levels of 5.0-5.5, ≥5.5-6.0, ≥6.0-6.5, ≥6.5-7.0 and ≥7.0 mmol/L were 57.5%, 22.8%, 10.1%, 4.7% and 4.9%, respectively. In patients with CKD, HF, DM and HTN, the proportions of patients who experienced HK were 47.7%, 29.1%, 21.7% and 10.2%, respectively. Analysing the severity of HK in HK patients with CKD, HF, DM and HTN, the proportions of patients with S-K levels ≥5.5 were higher than that in overall ED patients. (Table). Geographic analysis showed that provinces with higher proportions of HK were Tianjin (6.2%), Jiangsu (6.1%) and Jilin (5.7%). Higher proportion of HK were observed in winter (4.1%) than in summer (2.9%).
Conclusion
The proportions of HK in ED patients with CKD, HF, HTN or DM were higher than that in overall ED patients, and the severity of HK increased in patients with CKD, HF, DM and HTN.
The composition of patients at different S-K intervals in hyperkalemia patients with/ without CKD, HF, HTN, or DM in ED
| S-K (mmol/L) | CKD, N (%) | HF, N (%) | DM, N (%) | HTN, N (%) | Patients without CKD, HF, DM or HTN, N (%) |
| 5.0< K <5.5 | 1165 (38.6) | 1786 (49.9) | 1832 (49.4) | 2018 (54.1) | 14755 (65.3) |
| 5.5≤ K <6.0 | 822 (27.2) | 910 (25.4) | 955 (25.7) | 916 (24.6) | 4554 (20.2) |
| 6.0≤ K <6.5 | 457 (15.1) | 471 (13.2) | 458 (12.4) | 393 (10.5) | 1775 (7.9) |
| 6.5≤ K <7.0 | 257 (8.5) | 205 (5.7) | 230 (6.2) | 196 (5.3) | 703 (3.1) |
| K ≥7.0 | 320 (10.6) | 209 (5.8) | 235 (6.3) | 204 (5.5) | 789 (3.5) |
| Overall | 3021 (100) | 3581 (100) | 3710 (100) | 3727 (100) | 22576 (100) |