Abstract: PO0992
Outcomes of Diabetic vs. Non-Diabetic Patients in the GCC Dialysis Outcomes and Practice Patterns Study
Session Information
- Diabetic Kidney Disease: Clinical - 1
October 22, 2020 | Location: On-Demand
Abstract Time: 10:00 AM - 12:00 PM
Category: Diabetic Kidney Disease
- 602 Diabetic Kidney Disease: Clinical
Authors
- Bieber, Brian, Arbor Research Collaborative for Health, Ann Arbor, Michigan, United States
- Al-Ghamdi, Saeed, King Abdulaziz University, Jeddah, Saudi Arabia
- Al Rukhaimi, Mona, Dubai Medical College, Dubai, United Arab Emirates
- AlSahow, Ali, Jahra Hospital, Jahra, Kuwait
- Al Salmi, Issa, The Royal Hospital, Ministry of Health, Muscat, Oman
- Al-Ali, Fadwa M., Hamad General Hospital, Doha, Qatar
- Alaradi, Ali, Salmaniya Medical Complex, Manama, Bahrain
- Robinson, Bruce M., Arbor Research Collaborative for Health, Ann Arbor, Michigan, United States
- Pisoni, Ronald L., Arbor Research Collaborative for Health, Ann Arbor, Michigan, United States
Group or Team Name
- On behalf of the GCC-DOPPS Study Group
Background
Diabetes is a common comorbidity among hemodialysis (HD) patients in the Gulf Cooperation Council (GCC) countries, higher than any other region participating in the Dialysis Outcomes and Practice Patterns Study (DOPPS). Objectives of this analysis were to describe the prevalence of glycated-hemoglobulin (HbA1c) measurement, distribution of HbA1c, and association of HbA1c with mortality among participants in the GCC DOPPS.
Methods
2,274 HD patients were analyzed from 6 GCC (Bahrain, Kuwait, Oman, Qatar, Saudi Arabia, United Arab Emirates) participating in DOPPS phase 5 (2012-2015) and 6 (2015-2018). Diabetic status was based on cause of ESKD or medical chart diagnosis. Cox regression was used to assess the associations of diabetes (among all GCC patients) and baseline HbA1c (among diabetic patients) with mortality adjusted for demographics, comorbidities, creatinine, and Kt/V.
Results
Overall 60% of GCC DOPPS participants were diabetic (country prevalence ranged from 45% in Saudi Arabia to 74% in Kuwait). Compared to non-diabetic patients, patients with diabetes were older (60 vs. 47) on dialysis fewer years (1.5 vs. 3.0), and had higher BMI (27.6 vs. 24.9). Diabetes was associated with elevated mortality; adjusted HR(95% CI)=1.69(1.21-2.34). Measurement of HbA1c within the four months prior to enrollment was variable – ranging from 0% in Bahrain and 33% in Saudi Arabia to 60-78% in the other GCC countries. Among diabetic patients with HbA1c measured, median [IQR] HbA1c was 6.8 [5.8-7.1]. A moderate U-shaped relationship with HbA1c and mortality was observed after adjustment.
Conclusion
Although diabetes is highly prevalent in the GCC HD population, measurement of HbA1c remains variable among this population. The relationship of HbA1c with mortality appears similar to that see in other DOPPS regions. Further investigation related to frequency of measurement and control of HbA1c via treatment is warranted.
Funding
- Commercial Support –