Kidney Week

Abstract: PO2152

The Klotho Deficiency and Not the FGF-23 Rise Is Associated with Heart Failure with Reduced Left Ventricular Ejection Fraction in Patients with Preserved Kidney Function

Session Information

• Mechanisms of Kidney and Vascular Disease
  October 22, 2020 | Location: On-Demand
  Abstract Time: 10:00 AM - 12:00 PM

Category: Hypertension and CVD

• 1403 Hypertension and CVD: Mechanisms

Authors

• Aloui, Sabra, Department of Nephrology Monastir University, Monastir, Tunisia

Sabra Aloui,

• Lamti, Feten, Department of Nephrology Monastir University, Monastir, Tunisia

Feten Lamti,

• Letaief, Ahmed, Department of Nephrology Monastir University, Monastir, Tunisia

Ahmed Letaief,

• Hamouda, Mouna, Department of Nephrology Monastir University, Monastir, Tunisia

Mouna Hamouda,

• Ben salem, Meriem, Department of Nephrology Monastir University, Monastir, Tunisia

Meriem Ben salem,

• Ben salah, Manel, Department of Nephrology Monastir University, Monastir, Tunisia

Manel Ben salah,

• Handous, Insaf, Department of Nephrology Monastir University, Monastir, Tunisia

Insaf Handous,

• Skhiri, Habib, Department of Nephrology Monastir University, Monastir, Tunisia

Habib Skhiri,

• Ferchichi, Salima, Department of Biochemestry F HACHED, Sousse, Tunisia

Salima Ferchichi,

• Nouira, Samir, Department of Emergency Medecine, Monastir, Tunisia

Samir Nouira,

Background

The FGF23-Klotho axis is increasingly implicated in the pathophysiology of heart failure, especially during advanced chronic kidney disease (CKD).
Our objective is to study the association between this FGF23-Khloto axis and heart failure in patients without CKD.This topic is less studied in medical literature

Methods

This is a cross-sectional study of the FGF23 assessment, Klotho and the rest of the phosphocalcic assessment covering 70 patients with normal renal function. These patients had echocardiographic exploration which made it possible to distribute them in two groups: Group HF: LVEF(Left Ventricular Ejection Fraction)<55% (n = 18); Group NoHF: LVEF> 55% (n = 52) . Heart failure(HF) was exclusively of ischemic origin.

Results

These were 36 women and 34 men, average age 58 + - 10 years with an estimated glomerular filtration rate (eGFR) at an average of 92 ml / min / 1.73m². No difference in eGFR between the two groups.
Klotho was far lower with a statistically significant difference in Group HF. FGF23 was higher in Group HF but the difference was not statistically significant.
PTH (parathyroid hormone)was statistically higher in Group HF and calcemia was statistically lower in Group HF.
Phosphatemia and vitamin D were not associated with heart failure.

Conclusion

Although the sample studied is not large, Klotho but not FGF23 is strongly associated with systolic heart failure.This and other results will be further discussed.