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Kidney Week

Abstract: PO0492

Life's Simple 7 and CKD Progression: Results from the Mexico Chronic Renal Insufficiency Cohort (MCRIC) Study

Session Information

Category: CKD (Non-Dialysis)

  • 2101 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

  • Madero, Magdalena, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico, Estado de Mexico, Mexico
  • Hernandez Martinez, Ana Paulina, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico, Estado de Mexico, Mexico
  • Fernandez Yepez, Ana Karen, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico, Estado de Mexico, Mexico
  • Chen, Jinsong, University of Illinois at Chicago, Chicago, Illinois, United States
  • Larkin, Claire T., University of Illinois at Chicago, Chicago, Illinois, United States
  • Meza, Natalie, University of Illinois at Chicago, Chicago, Illinois, United States
  • Carmona, Eunice, University of Illinois at Chicago, Chicago, Illinois, United States
  • Viamontes, Christopher George, University of Illinois at Chicago, Chicago, Illinois, United States
  • Morales Cruz, Carlos Levi, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico, Estado de Mexico, Mexico
  • Vasquez Vasquez, Zuleyma Teresa, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico, Estado de Mexico, Mexico
  • Ramos Estrada, Tania Jazmin, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico, Estado de Mexico, Mexico
  • Avalos Galicia, Areli de Jesus, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico, Estado de Mexico, Mexico
  • Moguel, Bernardo, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico, Estado de Mexico, Mexico
  • Linares Koloffon, Carlos, University of Illinois at Chicago, Chicago, Illinois, United States
  • Ricardo, Ana C., University of Illinois at Chicago, Chicago, Illinois, United States
  • Lash, James P., University of Illinois at Chicago, Chicago, Illinois, United States
Background

The American Heart Association developed the Life’s Simple 7 metric to promote cardiovascular health. We evaluated the association of this metric with chronic kidney disease (CKD) progression among individuals with CKD living in Mexico.

Methods

MCRIC is an ongoing, prospective observational cohort study of adults with CKD recruited in Mexico City, with entry estimated glomerular filtration rate (eGFR) 20-70 ml/min/1.73 m2. Using data from 371 participants, we conducted Cox proportional hazards regression analysis to evaluate the association between Life’s Simple 7 (score range 0-14) and CKD progression (30% decline in eGFR from baseline). Ideal cardiovascular health was defined as nonsmoker; body mass index <25 kg/m2; ≥150 minutes/week of physical activity; healthy dietary pattern (high in fruits and vegetables, fish, and fiber-rich whole grains; low in sodium and sugar-sweetened beverages); total cholesterol <200 mg/dL; blood pressure <120/80 mm Hg; and fasting blood glucose <100 mg/dL).

Results

At study entry, mean age was 57 years, 71% were male, and 57% had diabetes. The mean baseline eGFR was 47 ml/min/1.73m2, and the median urine protein excretion 633 mg/24 hours. Nine percent met all seven criteria for ideal cardiovascular health. During a median follow-up of 2.9 years, there were 78 CKD progression events. In sex- and age-adjusted analysis, each point higher Life's Simple 7 score was associated with 13% lower risk of CKD progression (HR, 95% CI, 0.87, 0.78-0.96). This association attenuated after adjusting for baseline eGFR and proteinuria (0.94, 0.83-1.05).

Conclusion

In this cohort of adults with CKD in Mexico, the prevalence of ideal cardiovascular health as measured by Life’s Simple 7 was low. The protective effect of Life’s Simple 7 on CKD progression was explained by baseline kidney function.

Funding

  • NIDDK Support