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ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

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Kidney Week

Abstract: PO0466

Short-Term Associations of Triglycerides with Atherosclerotic and Non-Atherosclerotic Cardiovascular Disease Hospitalizations Across CKD Stages

Session Information

Category: CKD (Non-Dialysis)

  • 2101 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention


  • Soohoo, Melissa, VA Long Beach Healthcare System, Long Beach, California, United States
  • Hsiung, Jui-Ting, VA Long Beach Healthcare System, Long Beach, California, United States
  • Kovesdy, Csaba P., Memphis VA Medical Center, Memphis, Tennessee, United States
  • Kalantar-Zadeh, Kamyar, Harold Simmons Center for Kidney Disease Research and Epidemiology, Orange, California, United States
  • Streja, Elani, VA Long Beach Healthcare System, Long Beach, California, United States

In chronic kidney disease (CKD) patients, we showed that the risk of atherosclerotic cardiovascular disease (ASCVD) and non-ASCVD events with high baseline triglycerides (TG) incrementally attenuated across worse CKD stages, where high TG was associated with lower risk of non-ASCVD events in late-stage CKD. TG levels can change with CKD progression, but associations of time-varying TG with ASCVD or non-ASCVD hospitalizations is unknown.


We examined time-varying TG with time to first ASCVD or non-ASCVD hospitalization in 2,963,176 US veterans who received care in 2004-2006 (baseline) and were followed to 2014. Events were classified by primary ICD-9 codes. Using time-varying Cox models, we evaluated associations of time-varying TG with first ASCVD or non-ASCVD events stratified by baseline CKD stage, with adjustment for demographics, and time-varying comorbidities and laboratory values.


The cohort was 63±14 years old with a median[IQR]TG 127[87,189] mg/dL, and 23% had CKD 3A or higher at baseline. TG <80 mg/dL was associated with a lower risk of time to first ASCVD event (ref: TG 120-<160 mg/dL) for all baseline CKD stages (Fig A). There was a linear association between time-varying TG and ASCVD events. High TG≥240 mg/dL had the highest risks for ASCVD, for baseline non-CKD, and CKD 3A-3B. Among late-stage CKD patients, the association of high TG and ASCVD was null. We observed an inverse association between time-varying TG with time to first non-ASCVD event (Fig B). Patients with low TG had faster times to first non-ASCVD event for non-CKD and CKD 3A-4, while high TG were associated with slower times in all stages. CKD stage 5/end-stage renal disease patients with TG ≥240 mg/dL had the lowest risk of non-ASCVD event.


Short-term risk of higher TG with ASCVD or non-ASCVD events incrementally decreased across CKD stages, where risk was lower to null in late stage patients. High TG were associated with lower risks of non-ASCVD across all CKD stages. Investigation is needed to evaluate the pathways involving TG and cardiac events as CKD severity progresses in order to best manage health.