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Kidney Week

Abstract: PO2254

Fecal Calprotectin Correlates with Serum Albumin in Patients with CKD

Session Information

Category: Pathology and Lab Medicine

  • 1602 Pathology and Lab Medicine: Clinical

Authors

  • Chae, Yura, The Catholic University of Korea, Seoul, Korea (the Republic of)
  • Koh, Eun Sil, The Catholic University of Korea, Seoul, Korea (the Republic of)
  • Son, Jongho, The Catholic University of Korea, Seoul, Korea (the Republic of)
  • Chung, Sungjin, The Catholic University of Korea, Seoul, Korea (the Republic of)
Background

Persistent inflammation, a characteristic feature in chronic kidney disease, contributes to decreased serum albumin levels and plays a central role in the Malnutrition, Inflammation and Atherosclerosis (MIA) syndrome, which is associated with poor clinical outcomes. Altered bowel habit is also a highly frequent status among patients with chronic kidney disease potentially due to their low fiber and fluid intake, medications, multiple comorbidities and dysbiosis of the gut microbiota. In this study, we have explored whether measurement of fecal calprotectin, a commonly used marker for increased neutrophil migration and local inflammation in gastrointestinal diseases, could reflect a state of low serum albumin in patients with chronic kidney disease.

Methods

Clinical and biochemical data including stool samples for calprotectin were collected from 579 cases of patients with no history of inflammatory bowel disease.

Results

Fecal calprotectin was not different according to estimated glomerular filtration rate, degree of proteinuria and medication of polystyrene sulfonate and ferrous sulfate. However, it was significantly and negatively correlated with serum albumin in patients (r=-0.107, p=0.010). Patients with higher tertile of fecal calprotectin were older and likely to have lower hematocrit. Multivariable linear regression analysis showed that fecal calprotectin was significantly correlated with serum albumin (β=-17.702, P=0.010).

Conclusion

These observations that serum albumin were significantly correlated with fecal calprotectin in patients with chronic kidney disease, suggest that the bowel inflammatory response may be another contributing factor.