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Kidney Week

Abstract: PO0094

Comparison of Clinical Characteristics of AKI in Patients with Glyphosate and Glufosinate Herbicide Poisoning

Session Information

Category: Acute Kidney Injury

  • 102 AKI: Clinical, Outcomes, and Trials

Authors

  • Sun, In O, Presbyterian Medical Center, Jeonju, Jeollabuk-do , Korea (the Republic of)
  • Cho, A young, Presbyterian Medical Center, Jeonju, Jeollabuk-do , Korea (the Republic of)
Background

This study aimed to investigate the clinical characteristics of acute kidney injury in patients with glyphosate and glufosinate herbicide poisoning.

Methods

From 2008 to 2019, 230 patients admitted to our hospital after glyphosate or glufosinate herbicide poisoning. We compared the clinical characteristics of acute kidney injury in patients with glyphosate (n=173) and glufosinate (n=57) herbicide poisoning.

Results

The patinets included 155 men and 75 women with a mean age of 59 years (range, 22-101 years). There were no differences in the clinical characteristics between glyphosate and glufosinate poisoning except for serum bicarbonate and intensive care unit admission. The serum bicarbonate level was lower in glufosinate intoxication than in glyphosate intoxication (19.8 ± 4.5 vs. 21.5 ± 3.9, p<0.01). In comparison with patients of glyphosate poisoning, patients with glufosinate poisoning experienced intubation (59.6% vs. 19.7%, P<0.01) and intensive care unit admission (68.4% vs. 38.2%, p<0.01) more frequently. The overall incidence of acute kidney injury was 38.3% in this study, and there was no difference between two groups (35.8% vs. 45.6%, p=0.123).

Conclusion

Patients with glufosinate intoxication showed more severe type of clinical manifestation and intensive care unit admission rates than glyphosate intoxication.