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Kidney Week

Abstract: PO0095

Clinical Significance of Hypoalbuminemia for AKI in Patients with Scrub Typhus

Session Information

Category: Acute Kidney Injury

  • 102 AKI: Clinical, Outcomes, and Trials


  • Sun, In O, Presbyterian Medical Center, Jeonju, Jeollabuk-do , Korea (the Republic of)
  • Cho, A young, Presbyterian Medical Center, Jeonju, Jeollabuk-do , Korea (the Republic of)

The aim of this study is to investigate the clinical significance of hypoalguminemia for acute kidney injury in patients with scrub typhus.


From 2009 to 2018, 611 patients were diagnosed with scrub typhus. We divided the patients into two groups (normoalbuminemia vs. hypoalbuminemia) based on the serum albumin level of 3.0 g/dL, and compared the incidence, clinical characteristics, and severity of acute kidney injury based on RIFLE classification between two groups.


Of the total 611 patients, 78 (12.8%) were categorized as hypoalbuminemia group. Compared with patients in normoalbuminemia group, patients in hypoalbuminemia group were older (73 ± 9 vs. 62 ± 14, p<0.01) and had higher total leukocyte counts (10.2 × 103/mL vs. 6.7 × 103/mL, p<0.01). Hypoalbuminemia group showed significantly longer hospital stay (9.6 ± 6.1 vs. 6.1 ± 3.0, p<0.01) and higher incidence of complications in respiratory system (50% vs. 14%, p<0.01), cardiovascular system (28% vs. 11%, p<0.01), neurologic system. Furthermore, acute kidney injury (58% vs. 18%, p<0.01) was also developed in hypoalbuminemia group. The overall incidence of acute kidney injury was 23.1%; of which, 14.9%, 7.0% and 1.2% were classified as Risk, Injury and Failure, respectively. The serum albumin level correlated with acute kidney injury severity ( 3.4 ± 0.5 vs. 3.0 ± 0.5 vs. 2.6 ± 0.3, p<0.05). In a multivariate logistic regression analysis for predicting acute kidney injury, age, presence of co-morbidities such as chronic kidney disease, diabetes, or hypertension, total bilirubin, leukocytosis and hypoalbuminemia were significant predictors of acute kidney injury.


Hypoalbuminemia was closely associated with scrub typhus associated with acute kidney injury.