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Abstract: PO0970

The Application of Estimated Glomerular Filtration Rate Equations in Diabetic Kidney Disease Patients

Session Information

Category: Diabetic Kidney Disease

  • 602 Diabetic Kidney Disease: Clinical

Authors

  • Li, Ming, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China
  • Li, Canming, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China
  • Ye, Zengchun, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China
  • Peng, Hui, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China
Background

To evaluate the application of formulas based on serum creatinine and cystadin-C levels in Chinese patients with type2 DM.

Methods

224 type-2 DM patients were included in this study. Take the 99mTc-DTPA-GFR (sGFR) which standardization by Body Surface Area(BSA) as the golden standard. Estimated GFR (eGFR) was calculated respectively with abbreviated MDRD equation, modify and abbreviated MDRD equation, Cockcroft-Gault equation, CKD-EPI equation, RuJin equation, EPI-Cys2 equation. eGFR were compared with 99mTc-DTPA-GFR (sGFR).

Results

(1)Bland-Altman analysis results demonstrated that consistency of EPI-Cys2 equation and RuJin with sGFR were better than other equation, but all the equation were above the limite professional point. The slopes of EPI-Cys2 equation were closer to the identical line. (2)Bias of EPI-Cys2 equation was smaller than other equations. EPI-Cys2 equation underestimated actual GFR and other equations overestimated GFR. 30% and 50% accuracy rate of Ruijin equation and EPI-Cys2 equation were higher than other equations. (3)As to diagnosis CKD in DM patients, EPI-Cys2 equation was more sensitive and acurrate, and the cut-point of EPI-Cys2 equation and Ruijin equation was closer to 60ml/min.

Conclusion

All six equations show bias in estimating actual GFR. Compared with the equations induced by plasma creatine, EPI-Cys2 equation was more accurate and efficient,and followed by Ruijin equation.All equations should be amended when applying to Chinese DM patients.

Funding

  • Government Support - Non-U.S.