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Abstract: PO2611

Sexual Dimorphism and Hard Outcomes in AKI: Is Female Sex Protective? The Jury Is Still Out

Session Information

Category: Women’s Health and Kidney Diseases

  • 2000 Women’s Health and Kidney Diseases

Authors

  • Acosta-Ochoa, Maria Isabel, Hospital Clinico Universitario de Valladolid, Valladolid, Castilla y León, Spain
  • Coca, Armando, Hospital Clinico Universitario de Valladolid, Valladolid, Castilla y León, Spain
  • Sanchez Gil, Jimmy R., Hospital Clinico Universitario de Valladolid, Valladolid, Castilla y León, Spain
  • Mendiluce, Alicia, Hospital Clinico Universitario de Valladolid, Valladolid, Castilla y León, Spain
Background

Many studies focus on sex dimorphism and it's influence on hard outcomes when suffering an AKI episode. Some report that women, while others report that men are protected against adverse clinical events. In a real world cohort of individuals suffering from AKI, we compared hard outcomes between sexes with a novel approach: paired-matched study.

Methods

Retrospective paired-matched study of in-patients with AKI diagnosis; cases were matched based on sex, age and Charlson’s Index. We used KDIGO-2012 criteria to define AKI, analyzed clinical variables, and compared the hard outcomes: length of hospital stay, need for acute HD, HD dependence at discharge, and in-hospital mortality.

Results

We included 383-paired matches. Male individuals suffered from peripheral arterial disease and COPD, and were hospitalized in surgical wards more frequently than women. We found no statistically significant difference between groups regarding to the prevalence of common comorbidities and admission to ICU (Table 1A). The distribution in global KDIGO-AKI Stages was similar, but when analyzing every sub-criterion of the classification we found that women fulfilled the serum creatinine (SCr) increment ≥1.5-1.9x more frequently, and men fulfilled reaching a SCr >4 mg/dl more commonly. We found no statiscally significant differences in hospital stay, need for acute HD, HD dependence at discharge, and in-hospital mortality (Table 1 B).

Conclusion

To our knowledge, a paired-matched design regarding to this topic has not been previously published. Although experimental studies find differences in clinical outcomes between sexes when suffering an AKI episode, in this real world study, we did not observe a clear distinction in the incidence of adverse outcomes between sexes. We conclude that sex (either female or male) may not be protective against AKI’s hard outcomes.