Abstract: PO1438
Peripheral Administration of 3% Sodium Chloride Is Not Associated with Local Infusion Reactions
Session Information
- Fluid, Electrolyte, and Acid-Base Disorders: Clinical - 1
October 22, 2020 | Location: On-Demand
Abstract Time: 10:00 AM - 12:00 PM
Category: Fluid, Electrolyte, and Acid-Base Disorders
- 902 Fluid, Electrolyte, and Acid-Base Disorders: Clinical
Authors
- Moritz, Michael L., University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States
- Ayus, Juan Carlos, Renal Consultants of Houston, Houston, Texas, United States
- Nelson, Joel B., University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States
Background
Three-percent sodium chloride (3% NaCl) is a hyperosmolar agent indicated for the treatment of hyponatremic encephalopathy or to raise the serum osmolality in other cases of increased intracranial pressure. A barrier to the use of 3% NaCl is the perceived risk of a local infusion reactions when administered through a peripheral vein (Front Med. 2019 Mar 15;6:47), even though it has not been reported in large case series of 3% NaCl (AJKD. 2015 Mar;65(3):435-42). We sought to evaluate reports of local infusion reactions associated with 3% NaCl over a 10-year-period throughout a large healthcare system.
Methods
A query was conducted through Risk Master database to determine if there were any local infusion reactions associated with peripheral 3% NaCl administration throughout the entire UPMC health system over a 10-year time period from May 14, 2010 to May 14, 2020. Search terms included infiltrations, extravasations, phlebitis, IV site issues and IV solutions.
Results
In over 1.1 million events (figure), there were 23,714 intravenous events which were non-chemotherapeutic or non-contrast of which 4,648 (19.7%) were in children. 617 (2.59%) of these events were deemed serious by a patient safety officer. There were no reported local infusion reactions with 3% NaCl.
Conclusion
There were no reported local infusion reactions events associated with 3% NaCl in a large healthcare system despite widespread use of 3% NaCl and numerous intravenous events reported. This suggests that 3% NaCl can be safely administered through a peripheral IV.
Local Intravenous Infusion Reactions