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Abstract: PO0369

Effects of a Reduced Phosphorous Diet on the Circulating Metabolome in Healthy Adults

Session Information

Category: Bone and Mineral Metabolism

  • 402 Bone and Mineral Metabolism: Clinical

Authors

  • Paul, Shejuti, University of Alabama at Birmingham, Birmingham, Alabama, United States
  • Gutierrez, Orlando M., University of Alabama at Birmingham, Birmingham, Alabama, United States
Background

Excess phosphorus intake is linked to hypertension, heart failure, and disorders of bone and mineral metabolism. The reasons for these associations are unclear. Most prior work on the effects of diet phospohrus have focused on changes in specific endocrine factors in the blood. Less is known about the effects of nutritional phosphorus intake on the human metabolome, which represents the integrated biologic response to changes in diet.

Methods

In 37 healthy adults, we performed a global metabolomic analysis using untargeted mass spectrometry in plasma samples obtained after consuming a high phosphorus diet (1900/day) for 2 weeks (considered baseline for this study) and after consuming a reduced phosphorus diet (1200 mg/day) fo 6 weeks. Metabolomic profiling was conducted by Metabolon, Inc. using standard protocols. Matched pairs t-tests were used to identify analytes that significantly changed from baseline to six weeks, with each individual serving as his or her own control.

Results

The mean age of study participants was 34±12 years, 36% were black and 49% were men. A total of 222 metabolites significantly changed from baseline to six weeks on a reduced phosphorus diet using a false discovery rate < 0.05 to take into account multiple comparisons. Major analytes which differed in six-week vs. baseline samples included metabolites related to tryptophan metabolism, microbiome related biochemicals, urea cycle, bile acids, corticosteroids and androgenic steroids, and acyl carnitines. Changes in specific analytes of note within each of these pathways are depicted in the Figure.

Conclusion

In healthy adults, a reduced phosphorus diet altered metabolites related to the microbiome, urea cycle, steroid hormones, energy and lipid metabolism.

Change in select metabolites in response to phosphorus-reduced diet

Funding

  • Private Foundation Support