Abstract: PO0776
COVID-19 in Kidney Transplant Recipients at New England's Largest Safety-Net Hospital
Session Information
- COVID-19: CKD and Transplant Patients
October 22, 2020 | Location: On-Demand
Abstract Time: 10:00 AM - 12:00 PM
Category: Coronavirus (COVID-19)
- 000 Coronavirus (COVID-19)
Authors
- Mahmoud, Hassan, Boston University, Boston, Massachusetts, United States
- Ghai, Sandeep, Boston University, Boston, Massachusetts, United States
- Francis, Jean M., Boston University, Boston, Massachusetts, United States
Background
The coronavirus disease 2019 (COVID-19) has led to a global pandemic as announced by the World Health Organization. Kidney transplant patients are thought to constitute a unique high risk group for severe COVID19 infection. Furthermore, disparities in health care have led to COVID-19 disproportionately affecting minority groups including African Americans and Hispanics.
Methods
We identified adult kidney transplant recipients who were admitted with COVID-19 between March, 15th and May 1st, 2020. We evaluated the demographic, clinical and laboratory data of all admitted patients. We also evaluated the presence of co-infections as well as decisions regarding immunosuppressant management.
Results
23 kidney transplant recipients who were hospitalized for COVID-19 were evaluated. 91% of our patients were of minority groups. 35% of patients required ICU admission, and 30% required mechanical ventilation. 40% of patients had associated coinfections in addition to COVID19. 87% of patients had variable degrees of AKI, 26% of patients with AKI required renal replacement therapy. Mortality rate in our population was 22%.
Upon admission to the hospital, our immunosuppressant therapeutic approach included stopping the antimetabolites and continuing with the calcineurin inhibitors (targeting trough level of 4 to 6 ng/dl for tacrolimus and 50 ng/dl for cyclosporine), and prednisone if patients were on steroids.
Conclusion
This report demonstrates higher rate of AKI, coinfection and mortality in kidney transplant patients in the setting of COVID19 as compared to general population.