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Abstract: PO0842

COVID-19 Renal Pathology Protocols and Pathology Practice in Latin America: Analysis from GlomCon Latin America Working Group (LGlomCon)

Session Information

Category: Coronavirus (COVID-19)

  • 000 Coronavirus (COVID-19)

Authors

  • Martinez-Chagolla, Blanca, Hospital General de Morelia Miguel Silva, Morelia, Michoacan, Mexico
  • Arellano-Mendez, Denisse, Unidad Medica de Atencion Ambulatoria 254, IMSS, Morelia, Michoacan, Mexico
  • Aguirre, Diana, Hospital General de Mexicali, Mexicali, Baja California, Mexico
  • Garcia Anton, Desiree, University of Mississippi Medical Center, Jackson, Mississippi, United States
  • Gutierrez-Prieto, Julio Alejandro, Hospital Central del Estado de Chihuahua, Chihuahua, Chihuahua, Mexico
  • Rodriguez Ramirez, Sonia, Multi-Organ Transplant Program, University Health Network, Toronto, Ontario, Canada
  • Soto-Vargas, Javier, Hospital General Regional 46 IMSS, Guadalajara, Jalisco, Mexico
  • Cabeza Rivera, Franco H., University of Mississippi Medical Center, Jackson, Mississippi, United States
  • Avila-Casado, Carmen, Pathology Department, University Health Network, Toronto, Ontario, Canada

Group or Team Name

  • GlonCon Latin America Working Group
Background

A significant fraction of patients with COVID-19 display renal involvement (60%); however, the histological findings and pathology practice in Latin America (LA) have not been reported. The aim is to know how COVID-19 pandemic has affected the protocols for renal pathology and the main pathology findings in the kidney.

Methods

An online survey with 75 questions in 6 sections, directed to pathologists, nephrologists and other specialists from 16 Spanish speaking LA countries treating COVID patients with kidney involvement. We are analyzing the impact of COVID-19 in renal pathology and pathology practice in LA.

Results

From 430 responses, 360 (84%) were considered for analysis. Only13 participants from 16 countries were renal pathologists but the rest of responders also contributed with the pathology section. Only 10% is performing renal biopsies (RBx) of COVID-19 patients. Acute kidney injury (AKI) (85%) was the most frequent indication for RBx, hematuria-proteinuria (42%), nephrotic syndrome (28%) and subnephrotic proteinuria (21%). Combination of AKI and other syndrome was seen. Handling fresh tissue for immunofluorescence (IF) is a regular practice in the centers that perform IF (66%). No ultrastructural examination in 90% due to the lack of EM equipment. Postmortem studies only in 3% of the centers. Autopsy and biopsies shiwed thrombotic microangiopathy (TMA), with acute tubular injury (ATI). Pathology redeployment to clinical areas, ICU and inpatient care is seen in 12% . Only 70% of those received guidance or updating clinical courses.

Conclusion

The survey has highlighted the deep shortage of renal pathologists and the lack of equipment (EM) compromising the best practice of renal pathology in LA. Protocols for tissue handling for COVID have not been established in any center, adding a burden to the practice. Most frequent indication for renal biopsy is AKI while the presence of TMA and ATI is found in autopsy and renal samples. Collapsing glomerulopathy (CG) has a high prevalence in hispanics and has been described in COVID patients, however CG was not seen. Outbreaks had forzed pathology redeployment to clinical care without proper preparation.