ASN's Mission

ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005

email@asn-online.org

202-640-4660

The Latest on Twitter

Kidney Week

Abstract: PO1154

Peak Oxygen Capacity in Patients on Dialysis: The Role of Fluid Overload

Session Information

Category: Dialysis

  • 701 Dialysis: Hemodialysis and Frequent Dialysis

Authors

  • Gomes, Vanessa Oliveira, Universidade de Sao Paulo Hospital das Clinicas, São Paulo, São Paulo, Brazil
  • Viana, Marília Pena, Universidade de Sao Paulo Hospital das Clinicas, São Paulo, São Paulo, Brazil
  • Benavides, Lizbeth Chamorro, Universidade de Sao Paulo Hospital das Clinicas, São Paulo, São Paulo, Brazil
  • Menezes filho, Marcelo P., Universidade de Sao Paulo Hospital das Clinicas, São Paulo, São Paulo, Brazil
  • Pantoja, Jose Mariano Soriano, Universidade de Sao Paulo Hospital das Clinicas, São Paulo, São Paulo, Brazil
  • Soares, Luana Raposo, Universidade de Sao Paulo Hospital das Clinicas, São Paulo, São Paulo, Brazil
  • Silva, Jukelson Barbosa, Universidade de Sao Paulo Hospital das Clinicas, São Paulo, São Paulo, Brazil
  • Feitosa, Valkercyo Araújo, Universidade de Sao Paulo Hospital das Clinicas, São Paulo, São Paulo, Brazil
  • Moyses, Rosa M.A., Universidade de Sao Paulo Hospital das Clinicas, São Paulo, São Paulo, Brazil
  • Elias, Rosilene M., Universidade de Sao Paulo Hospital das Clinicas, São Paulo, São Paulo, Brazil
Background

Exercise capacity is predictive of cardiovascular disease and mortality in patients with chronic kidney disease on dialysis. Fluid overload, a common feature in these patients, may play a role in this pathophysiology.

Methods

The Duke Activity Status Index (DASI) questionnaire was administered to 27 patients on peritoneal dialysis (PD) and 82 patients on hemodialysis (HD). Results were expressed as peak oxygen uptake (Vo2peak, ml/kg/min). Electrical bioimpedance was applied to assess body composition. Fluid overload was assessed as the ratio of extracellular water/total body water (ECW/TBW).

Results

The patients on HD and PD have no difference in age (44 ± 15 vs. 49 ± 18 years, p=0.224) and body mass index (25.0 ± 4.9 vs. 26.3 ± 4.9kg/m2, p=0.245), with similar gender distribution (p=0.870), prevalence of diabetes (p=0.404) and smoking habit (p=0.223). Vo2peak was lower among patients on PD than HD (21.4 ± 7.5 vs. 25.3 ± 7.6ml/kg/min, respectively, p=0.023). Vo2peak correlated with ECW/TBW (r=-0.436, p=0.0001) and age (r=-0.483, p=0.0001) in both groups and within each group. Vo2peak correlated with interdialytic weight gain in patients on HD (r=-0.236, p=0.031).

Conclusion

Patients on dialysis present reduced exercise capacity, which is even more pronounced for patients on PD. Volume overload seems to be involved in this reduction and might be a target for interventional therapies.