Abstract: PO2415
Characteristics of Anonymous Living Donors and Their Recipients and Outcomes: Appropriate Use of a Rare and Valuable Gift
Session Information
- Clinical and Immunologic Predictors of Post-Transplant Outcomes
October 22, 2020 | Location: On-Demand
Abstract Time: 10:00 AM - 12:00 PM
Category: Transplantation
- 1902 Transplantation: Clinical
Authors
- Jan, Muhammad Yahya, Indiana University School of Medicine, Indianapolis, Indiana, United States
- Yaqub, Muhammad S., Indiana University School of Medicine, Indianapolis, Indiana, United States
- Adebiyi, Oluwafisayo O., Indiana University School of Medicine, Indianapolis, Indiana, United States
- Taber, Tim E., Indiana University School of Medicine, Indianapolis, Indiana, United States
- Sharfuddin, Asif A., Indiana University School of Medicine, Indianapolis, Indiana, United States
Background
Anonymous Living Donors are a special select set of donors.We review the trends and the characteristics and utilization of such donors nationally.
Methods
All Living Donors (code=10 "Anonymous") and their recipients who were recorded in the UNOS database from Oct 1997 through Sep 2017 were reviewed for demographics and recipient outcomes.
Results
There were a total of 2286 such donors during the study period. There was an increasing trend of the donors over the time period. Demographics and Outcomes are shown in the Table. DCGS was significantly superior when donor was 20 years or more younger than the Recipient (p=0.019) and significantly inferior when the 20 years older than the recipient (p=0.0005). There was no difference in cumulative graft survival between adult and pediatric graft survival (p=0.055), although DCGS was superior in the adults (p=0.021).
Conclusion
To our knowledge, this is the first comprehensive report on the characteristics of Anonymous Living Kidney Donors and their Recipients and outcomes. Better characteristics matching in a minority of such transplants may improve further longevity from such donors.
Donor, Recipient and Transplant Characteristics
| Donor Mean Age / Median (range) | 43.6±12.1/ 44 (18-76) yrs |
| Donor Race (W/AA/H) // Gender (M/F) % | 96.3/2.4/2.7 // 56.5/43.3 |
| Mean / Median (range) Donor BMI // h/o HTN (%) | 25.6±3.9 / 25.3(15-42) // 1.9% |
| Recipient Mean Age / Median (range) | 47.4±15.3 / 50 (1-79) |
| Recipient Race (W/AA/H) // Gender (M/F) % | 67.3/15.7/8.7 // 59.3/40.7 |
| Re-Transplants / Pre-emptive / PVD / DM % // Median Time Wait list | 12.2/ 23.3/ 4.8/ 27.1 // 462 days |
| Donor Nephrectomy Side (%) | Left 87.3 / Right 12.7 |
| 1 yr Rejection / DGF (%) | 7.9 / 4.9 |
| ABO MisMatch (%) | Identical 89.3/Compatible 9.8/ Incompatible 0.8 |
| HLA 0 MM / DR 0 MM | 1% / 9% |
| Age Mismatch Mean / Median (range) | 3.8±17 / 3.0 (-51 to 51) |
| BMI Mismatch (Recap-Donor) Mean/ Median (range) / >10 unit Difference (%) | 1.8±6.7/ 1.8 (-25 to 31) / 2.1% |
| Recipient Age > 20 yrs Older Than Donor (%) | 18.1 |
| Donor Age > 20 yrs Than Recipient (%) | 2.9 |
| 1 yr Rejection / DGF (%) | 7.9 / 4.9 |