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Abstract: PO0552

CKD and Metabolic Risk Factors: A Cross-Sectional Study Based on 398,120 Adults in China

Session Information

Category: CKD (Non-Dialysis)

  • 2102 CKD (Non-Dialysis): Clinical, Outcomes, and Trials

Authors

  • Xu, Lingling, Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
  • Liu, Jin, Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
  • Zhou, Yang, Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
  • Yang, Junwei, Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
Background

Chronic kidney disease (CKD) has become a worldwide health problem. The prevalence of CKD varied within countries by different socio-demographic characteristics and economic status. Olderly people are particularly susceptible to kidney damage from age-related decline in glomerular filtration and chronic disease states, such as diabetes mellitus (DM) and hypertension (HTN). It is necessary to understand the epidemiological features and the association risk factors of CKD in adults, especially in these elderly population.

Methods

We did a cross-sectional survey based on the records of universal health examinations of the residents in Binhai county of China in 2018. A total of 398,120 participants aged ≥ 18 years in this study had underwent blood test, body measurements and general demographic characteristics registration. Then 31.6% of subjects who aged ≥ 65 years (n=37,533) were randomly selected to complete the routine urinalysis. Chronic renal insufficient (CRI) was defined by eGFR < 60 mL/min.1.73 m2(CKD-EPI), while CKD was defined by CRI or presence of proteinuria. We analyzed the epidemiological features and the association between CKD and relevant covariates by logistic regression models in the general and elderly population.

Results

The age- and gender- standardized prevalence of CRI was estimated to be 1.10% (95% CI, 1.07%-1.13%) in Chinese adult population. It was 0.86% among men (95% CI, 0.82%-0.90%) and 1.34% among women (95% CI, 1.29%-1.39%). Female, aging, central obesity, elevated triglycerides, systolic blood pressure, fasting blood glucose (FBG) and heart rate were independent risk factors for CRI in the general adults. Rates of CRI increased significantly by age, especially when people aged ≥ 60 years. Furthermore, the prevalence of CKD was 17.7% (95% CI, 17.3%-18.1%) in the elderly. Aging, HTN, elevated triglyceride and FBG were still found to be independent risk factors for CKD in this subgroup. Elevated FBG had the strongest correlation with CKD, gender was no longer association with CKD in the elderly.

Conclusion

Aging, HTN, elevated triglyceride and FBG were all independent metabolic-related risk factors associated with CKD in Chinese adults. More attention should be paid to metabolic diseases such as DM, HTN and hyperlipidemia to prevent CKD in adults, especially in the elderly.

Funding

  • Government Support - Non-U.S.