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Abstract: SU-OR19

Low Birth Weight for Gestational Age and Risk of Different Groups of Kidney Disease During the First 50 Years of Life

Session Information

Category: CKD (Non-Dialysis)

  • 2101 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

  • Gjerde, Anna, Haugesund sjukehus, Haugesund, Norway
  • Skrunes, Rannveig, Universitetet i Bergen, Bergen, Hordaland, Norway
  • Marti, Hans-Peter, Universitetet i Bergen, Bergen, Hordaland, Norway
  • Vikse, Bjorn Egil, Haugesund sjukehus, Haugesund, Norway
Background

Previous studies have shown that Low Birth Weight (LBW) is associated with increased risk of end-stage renal disease. Few population based studies have investigated risk of Small for Gestational Age (SGA) on kidney disease.Our study investigates SGA and risk of chronic kidney disease (CKD), other kidney diagnoses as well as different stages of kidney failure.

Methods

The Norwegian Patient Registry (NPR) has registered ICD diagnostic codes for all admissions and outpatient visits to Norwegian hospitals since 2008.The Norwegian Medical Birth Registry (MBR) has registered birth weight, gestational age and several other data on maternal and offspring health for all birth in Norway since 1967. Data from these registries were linked and risk of CKD and other groups of kidney disease were analyzed with logistic regression statistics.
Based on birth weight, gestational age and gender, a z-score of birth weight for gestational age has been calculated.
SGA defined as birth weight less than the 10th percentile for gestational age and gender with cut-off -1.30 for male and -1.28 for female. LBW (less than the 10th percentile) and preterm birth (less than 37 weeks) were analyzed as risk markers. Adjusted analyses were performed for the main analyses by including birth year, gender, maternal disease, maternal marital status and malformations in the newborn

Results

Of the 2,663,010 included sunjects, 4495 had been diagnosed with CKD and 12,818 with acute kidney disease, glomerulonephritis, hereditary kidney disease or kidney disease due to kidney or urinary tract malformations. SGA was associated with odds ratio (OR) for CKD of 1.79 (1.65-1.94), LBW with an OR of 1.72(1.59-1.86) and preterm birth with an OR of 1.48 (1.32-1.67). There were no significant gender differences. Analyses of CKD stage 3, 4 and 5 showed similar results. An adjusted odds ratio (aOR) for other groups of kidney disease showed that SGA was associated with aOR of 1.60 (1.49-1.73) for acute kidney disease, 1.18 (1.070-1.30) for glomerulonephritis, 1.31 (1.12-1.52) for hereditary kidney disease and 1.13 (1.03-1.23) for kidney disease due to kidney or urinary tract malformations

Conclusion

SGA is a strong risk maker for diagnosis of all stages of CKD during the first 50 years. The risks seem to increase also for other groups of kidney disease.