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Abstract: PO1896

Collapsing Glomerulopathy and Vascular Lesions

Session Information

Category: Glomerular Diseases

  • 1203 Glomerular Diseases: Clinical, Outcomes, and Trials

Authors

  • Luvizotto, Mateus Justi, Universidade de Sao Paulo, Sao Paulo, São Paulo, Brazil
  • Neves, Precil D., Universidade de Sao Paulo, Sao Paulo, São Paulo, Brazil
  • Dias, Cristiane B., Universidade de Sao Paulo, Sao Paulo, São Paulo, Brazil
  • Yu, Luis, Universidade de Sao Paulo, Sao Paulo, São Paulo, Brazil
  • Testagrossa, Leonardo, Universidade de Sao Paulo, Sao Paulo, São Paulo, Brazil
  • Malheiros, Denise M., Universidade de Sao Paulo, Sao Paulo, São Paulo, Brazil
  • Woronik, Viktoria, Universidade de Sao Paulo, Sao Paulo, São Paulo, Brazil
  • Jorge, Lectícia, Universidade de Sao Paulo, Sao Paulo, São Paulo, Brazil
Background

Collapsing Glomerulopathy (CG) has usually been associated with rapidly progressive renal failure. Some authors have found that vascular injury could be associated with poor outcomes. The goal of the study was to compare patients with and without vascular lesion on renal biopsy

Methods

A retrospective analysis was performed on all CG cases diagnosed by kidney biopsy between 1996 and 2019 at the University of Sao Paulo. Clinical and laboratory data were collected at baseline and at the end of follow up. We excluded cases of chronic viral infection(8 HIV, 4 HCV, 2 HBV) drugs, any suspected immune-mediated disease(4 SLE) and diabetes(3). We analyzed histological, clinical and follow-up data and compared patientes with and without vascular lesions in biopsy.

Results

Clinical features of the groups with and without vascular lesions are summarized in Table 1. There was no significant difference in gender, albumin,proteinuria, among the two groups. Moreover, the immunofluorescence of the renal biopsies showed no difference in IgM and C3 deposits in glomeruli. Patients with vascular lesions were older and presented with worse renal function.

Conclusion

Vascular lesion in CG is associated with worse renal function and it is more prevalant in older adults.