Abstract: PO1848
A Single-Center Retrospective Study of Thrombotic Microangiopathy
Session Information
- Glomerular Diseases: Clinical, Outcomes, and Trials - 1
October 22, 2020 | Location: On-Demand
Abstract Time: 10:00 AM - 12:00 PM
Category: Glomerular Diseases
- 1203 Glomerular Diseases: Clinical, Outcomes, and Trials
Authors
- Bustos, Aulio Elias, Westchester Medical Center Health Network, Valhalla, New York, United States
- Chugh, Savneek S., Westchester Medical Center Health Network, Valhalla, New York, United States
- Gupta, Sanjeev, Westchester Medical Center Health Network, Valhalla, New York, United States
- Deval, Neha, Westchester Medical Center Health Network, Valhalla, New York, United States
- Jafri, Firas, Westchester Medical Center Health Network, Valhalla, New York, United States
- Khosla, Jagjit, Westchester Medical Center Health Network, Valhalla, New York, United States
- Mangaroliya, Vrunda, Westchester Medical Center Health Network, Valhalla, New York, United States
- Kore, Shruti, Westchester Medical Center Health Network, Valhalla, New York, United States
Background
Thrombotic microangiopathies (TMAs) are a rare group of clotting disorders of various origin, including infectious, idiopathic, autoimmune or drug-induced. This group shares common clinical manifestations that include low red blood cell and platelet counts. Although the disease is rare but treatable if clinician is aware about its manifestations. To increase the awareness and understand the disease better we conducted a retrospective study to characterize and assess TMAs in our institution
Methods
An observational retrospective study of patients with a diagnosis of TMA at Westchester Medical Center in the past 5 years was conducted. Data was collected from electronic medical records. Demographic, clinical and therapeutic variables were extracted, tabulated and analyzed
Results
A total of 43 patients with a diagnosis of TMA were identified and included in the study. The cohort had a mean age of 39.9 years; 20 were male and 23 females. As shown in Table 1. Thrombotic thrombocytopenia purpura (TTP) (n=14, 32%), systemic lupus erythematosus (SLE) (n=5, 11.6%), and hemolytic uremic syndrome (HUS) (n=5, 11.6%) are the most common etiologies. Other identifiable etiologies were atypical HUS (9%), use of calcineurin inhibitors (9%), acute myeloid leukemia (4.6%). About 6.9% cases didn’t have any identifiable cause (6.9%). Patients with TTP had a mean age of 48 years, mean platelet count of 17 k/mm3, and most were female (71%). Fifty-seven percent had hematuria, 21% proteinuria and 85% had schistocytes in the blood smear
Conclusion
Most common cause of thrombotic Microangiopathies is TTP which is what we found in our institution. It is essential to aware about the manifestation of this disease since early recognition and prompt treatment is the key for better outcome
Table 1
Etiology | TTP | SLE | HUS |
Number of cases | 14 | 5 | 5 |
Mean age, years | 48 | 30 | 16 |
Mean platelets count (k/mm3) | 17 | 105.4 | 53.8 |
Hematuria, % | 57 | 80 | 100 |
Proteinuria, % | 21 | 80 | 100 |
Schistocytes, % | 85 | 60 | 100 |
TTP, thrombotic thrombocytopenia purpura; SLE, systemic lupus erythematosus; HUS, hemolytic uremic syndrome