ASN's Mission

To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005


The Latest on X

Kidney Week

Please note that you are viewing an archived section from 2020 and some content may be unavailable. To unlock all content for 2020, please visit the archives.

Abstract: PO0765

COVID-19 and Kidney Transplantation: Results from the TANGO International Transplant Consortium

Session Information

Category: Coronavirus (COVID-19)

  • 000 Coronavirus (COVID-19)


  • Riella, Leonardo V., Massachusetts General Hospital, Boston, Massachusetts, United States
  • Sarvode mothi, Suraj, Brigham and Women's Hospital, Boston, Massachusetts, United States
  • Akalin, Enver, Montefiore Medical Center, Bronx, New York, United States
  • Cravedi, Paolo, Mount Sinai Health System, New York, New York, United States

Group or Team Name

  • TANGO Consortium

Chronic immunosuppression and comorbidities may expose kidney transplant recipients to an increased risk of developing critical coronavirus disease 2019 (COVID-19), but data in transplantation have been limited so far to single centers. To determine the clinical presentation, outcomes, and mortality risk factors in transplant patients with COVID-19, we analyzed retrospective data from a large international transplant consortium (TANGO Study).


Retrospective cohort study included kidney transplant recipients admitted with COVID-19 in 11 centers participating in the international TANGO consortium. We included all adult (>18 yeas) kidney transplant recipients with a functioning kidney allograft who were admitted to a hospital between March-April, 2020. Epidemiological, demographic, clinical, laboratory, treatment, and outcome data were extracted from electronic medical records using an ad hoc designed data collection form.


Among 9,697 kidney transplant recipients followed at 11 transplant centers, 145 (1.5%) were hospitalized due to COVID-19. 65% were male and more than half were over 60 years old (55%). Median time since transplant was 5 years (2-10) and only 16% were transplanted less than one year from the presentation. Prevalent comorbidities included hypertension (95%), obesity (41%), heart disease (25%) and lung disease (19%). Common symptoms at the onset of illness were fever and dyspnea (71%), followed by myalgia (54%) and diarrhea (35%). Management of anti-rejection therapy varied across centers: antimetabolites were withdrawn in 69% of patients and calcineurin inhibitor in 26%. Other treatments used during hospitalization included hydroxychloroquine (83%), antibiotics (76%), tocilizumab (13%) and antivirals (10%). During a median follow-up of 13 days (IQR: 7 - 21) after diagnosis of COVID-19, mortality was 30% and occurred at a median 10 (5-16) days after admission. Acute kidney injury (AKI) occurred in 46% and respiratory failure requiring intubation in 29% of cases. No rejection events were observed.


Our large international consortium indicates that kidney transplant recipients with COVID-19 have increased mortality (30%) upon hospitalization compared to the general population with a high rate of AKI (46%) and significant respiratory failure (29%).