Abstract: PO2325
Association of Environmental Tobacco Exposure with Blood Pressure in US Children
Session Information
- Pediatric Nephrology: Glomerular Disease and Transplantation
October 22, 2020 | Location: On-Demand
Abstract Time: 10:00 AM - 12:00 PM
Category: Pediatric Nephrology
- 1700 Pediatric Nephrology
Authors
- Levy, Rebecca, Albert Einstein College of Medicine, Bronx, New York, United States
- Brathwaite, Kaye E., Albert Einstein College of Medicine, Bronx, New York, United States
- Sarathy, Harini, University of California San Francisco, San Francisco, California, United States
- Reidy, Kimberly J., Albert Einstein College of Medicine, Bronx, New York, United States
- Kaskel, Frederick J., Albert Einstein College of Medicine, Bronx, New York, United States
- Melamed, Michal L., Albert Einstein College of Medicine, Bronx, New York, United States
Background
Hypertension is a leading cause of cardiovascular and kidney disease in adults, and there is evidence that pathologic sequelae begin in childhood and young adulthood. Nicotine and other tobacco compounds have a variety of toxic effects, but to date their associations with chronic hypertension is unclear, especially in pediatric populations.
Methods
We examined the association between tobacco exposure and high blood pressure (HBP) in children who participated the National Health And Nutrition Examination Survey (NHANES) during 2008-2016. Children were classified as having tobacco exposure if they had blood cotinine levels >0.05ng/dL or reported living with a smoker or smoking themselves. High blood pressure was classified according to the 2017 AAP Clinical Practice Guidelines. Analysis was conducted by logistic regression with adjustment for baseline demographics, income and other possible confounders. Subgroup and sensitivity analyses were conducted.
Results
There was a positive association of high blood pressure with tobacco exposure in the study population. After adjustment for demographics, the odds of having high blood pressure was 1.39 (95% Confidence Interval (CI) 1.04, 1.87) for any tobacco exposure compared to no smoking exposure. The association was similar across participant subgroups. The association remained significant by sensitivity analysis using cotinine exposure as a continuous variable. Separately, the odds of having high blood pressure for passive smokers was 1.35 (CI 0.983, 1.85) while the odds for active smokers was 1.71 (CI 1.14, 2.54) compared to participants with no tobacco exposure.
Conclusion
Tobacco exposure is associated with high blood pressure in US children and adolescents.
Association of Tobacco Exposure with High Blood Pressure
| Odds Ratio | Confidence Interval | p | |
| Model 1 (Unadjusted) | 1.66 | 1.27, 2.19 | <0.001 |
| Model 2 (Adjusted for age, sex, and race) | 1.62 | 1.22, 2.15 | 0.001 |
| Model 3 (Adjusted for age, sex, race, BMI category, poverty-income ratio category, and survey year) | 1.39 | 1.04, 1.88 | 0.029 |
Funding
- Other NIH Support