ASN's Mission

ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005

email@asn-online.org

202-640-4660

The Latest on Twitter

Kidney Week

Abstract: PO0688

Clinical Factors Associated with AKI in Patients with COVID-19 from a University Hospital in Brazil

Session Information

Category: Coronavirus (COVID-19)

  • 000 Coronavirus (COVID-19)

Authors

  • Chiloff, Daniela Mendes, Universidade Federal de Sao Paulo, Sao Paulo, São Paulo, Brazil
  • Maltoni, Isabela Soucin, Universidade Federal de Sao Paulo, Sao Paulo, São Paulo, Brazil
  • Sanches, Felipe Freitas Mascotte, Universidade Federal de Sao Paulo, Sao Paulo, São Paulo, Brazil
  • Coletti, Mariana Rebelatto, Universidade Federal de Sao Paulo, Sao Paulo, São Paulo, Brazil
  • Delfino, Caio C b, Universidade Federal de Sao Paulo, Sao Paulo, São Paulo, Brazil
  • Almeida, Isabela Guerreiro Veloso de, Universidade Federal de Sao Paulo, Sao Paulo, São Paulo, Brazil
  • Albeny, Letícia Carolina a m, Universidade Federal de Sao Paulo, Sao Paulo, São Paulo, Brazil
  • Araujo, Gabriel Napolitani de, Unisa, São Paulo, Brazil
  • Roizman, Renata G., Universidade Federal de Sao Paulo, Sao Paulo, São Paulo, Brazil
  • Zavadzki, Giovanna Melanie, Universidade Federal de Sao Paulo, Sao Paulo, São Paulo, Brazil
  • Goes, Miguel Angelo, Universidade Federal de Sao Paulo, Sao Paulo, São Paulo, Brazil
Background

Critically ill patients with COVID-19 frequently presents Acute kidney Injury (AKI) associated with increased mortality. However, there is paucity of data from Brazil. So, we analyzed factors in associated with AKI patients in a university hospital.

Methods

We conducted an observation with frequencies and association with binary logistic regression study in patients with COVID-19 hospitalized at Hospital Sao Paulo-Federal University of Sao Paulo. Diagnosis and classification of acute kidney injury (AKI) were by KDIGO. We examined the rates of renal function, mechanical ventilation (MV), renal replacement therapy (RRT), medications and in-hospital mortality.

Results

We observed a total of 172 in-patients with COVID-19. Patients were predominantly male (61,5%). We observed hypertension in 55%, diabetes 34%, smokers 27%, obesity (19%). Eighty-nine (52%) patients needed intensive care unit (ICU)], 70 (79%) cases of AKI were in ICU (31% of general ward admissions; p<0,001). In the ICU there were 78% needed mechanical ventilation, 36% in RRT, amine vasoactive 65% and mortality in 48%. AKI patients were older (61±15, 55±15; p=0.01), higher creatinine in admission (2.6±1.6, 1.3±0.7; p=002), higher RDW (14.7±1.5, 13.3±1.6; p=0.08), needed of MV (88%) and vasoactive amine (90%), RRT (88%) and higher mortality (87%). We used serum creatinine, age, RDW, mechanical ventilation and vasoactive amine in model of regression. We observed that MV (OR 1026 [CI95%, 1009-1038; p<0.001) and age (OR 1030 [CI95%, 1004-1056; p=0.002) were independently associated with AKI.

Conclusion

AKI is associated with high rates of RRT and death. Higher age and need of mechanical ventilation were associated with AKI in COVID-19 patients.

Funding

  • Government Support - Non-U.S.