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Abstract: PO1172

Effect of Hemodiafiltration with Medium Cut-Off Dialyzer on Uremic Toxins Removal

Session Information

Category: Dialysis

  • 701 Dialysis: Hemodialysis and Frequent Dialysis

Authors

  • Lopez Gil, Jose S., National Institute of Cardiology, Ignacio Chávez, Mexico, Mexico City, CDMX, Mexico
  • Armenta álvarez, Armando, National Institute of Cardiology, Ignacio Chávez, Mexico, Mexico City, CDMX, Mexico
  • Osuna Padilla, Ivan Armando, Centro de Investigacion en Enfermedades Infecciosas CIENI, Mexico City, CDMX, Mexico
  • Grobe, Nadja, Renal Research Institute, New York, New York, United States
  • Tao, Xia, Renal Research Institute, New York, New York, United States
  • Chao, Joshua Emmanuel, Renal Research Institute, New York, New York, United States
  • Raimann, Jochen G., Renal Research Institute, New York, New York, United States
  • Thijssen, Stephan, Renal Research Institute, New York, New York, United States
  • Dias, Gabriela Ferreira, Renal Research Institute, New York, New York, United States
  • Peng, Peiying, Renal Research Institute, New York, New York, United States
  • Wang, Xiaoling, Renal Research Institute, New York, New York, United States
  • Garza, Hector Alejandro Perez Grovas, National Institute of Cardiology, Ignacio Chávez, Mexico, Mexico City, CDMX, Mexico
  • Kotanko, Peter, Renal Research Institute, New York, New York, United States
  • Madero, Magdalena, National Institute of Cardiology, Ignacio Chávez, Mexico, Mexico City, CDMX, Mexico
Background

To our knowledge no study has ever evaluated the use of middle cut-off membranes (MCO) with online hemodiafiltration (OL-HDF). This study aims to show if the combination of OL-HDF with MCO can achieve a higher reduction ratio of some uremic toxins in comparison to regular OL-HDF

Methods

Patients from our hemodialysis unit were treated twice with four different modalities, namely combinations of post-dilutional OL-HDF or hemodialysis (HD) with a high-flux dialyzer (CordiaxFX120, area 2.5 m2) or the MCO (Theranova 400; area 1.7 m2), respectively. We analyzed the reduction ratios (RR) of erythropoietin, beta2-microglobulin (B2M), phosphate, and urea.

Results

Twelve anuric patients were studied (6 females; mean age 43.818.5 years; HD vintage 35.2 ± 27.8 months.) Mean blood flow (Qb) was 367 23 ml / min, dialysate flow (Qd) was 493 57 ml / min, ultrafiltration volume was 2382 5683 ml.
B2M RR of HDF+HiFlux was higher than HD+MCO (p=0.003), and HDF+MCO vs. HD+MCO (p=0.029). There was no difference in EPO, phosphate, and urea RR between any of the four groups.

Conclusion

Adding a medium cut-off (MCO) dialyzer to HDF does not add benefit. The B2M RR with HiFlux exceeds the one of a MCO dialyzer. HDF provides benefit over HD regarding the B2M RR regardless of the dialyzer used.

Funding

  • Commercial Support – Fresenius