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Abstract: PO1945

Renal Involvement in Granulomatosis with Polyangiitis Does Not Increase Inpatient Mortality Compared with No Renal Involvement

Session Information

Category: Glomerular Diseases

  • 1203 Glomerular Diseases: Clinical, Outcomes, and Trials

Authors

  • Edigin, Ehizogie, John H Stroger Hospital of Cook County, Chicago, Illinois, United States
  • Eseaton, Precious, University of Benin Teaching Hospital, Benin City, Edo, Nigeria
  • Manadan, Augustine, Rush University Medical Center, Chicago, Illinois, United States
Background

The aim of this study was to analyze the difference in outcomes of Granulomatosis with polyangiitis (GPA) with and without renal involvement. The primary outcome was inpatient mortality, while secondary outcomes were hospital length of stay (LOS) and total hospital charges.

Methods

Data were abstracted from the National Inpatient Sample (NIS) 2016 and 2017 Database. NIS is the largest inpatient admission database in the United States. The NIS was searched for adult GPA hospitalizations with and without renal involvement as the principal or secondary diagnosis using ICD-10 codes. Multivariate logistic and linear regression analysis was used to adjust for confounders for the primary and secondary outcomes respectively. STATA software was used to analyze the data.

Results

There over 71 million discharges included in the combined 2016 and 2017 NIS database. 23,670 hospitalizations were for adult patients, who had either a principal or secondary ICD-10 code for GPA. 8,265 (34.92%) and 15,405 (65.08%) of these hospitalizations were for GPA with renal and without renal involvement respectively. Inpatient mortality occurred in 1,010 GPA patients (5.1%). 425 (5.1%) of the deaths occurred in GPA with renal involvement vs 585 (3.8%) without renal involvement (p=0.0287). The adjusted odds ratio (AOR) of inpatient mortality for GPA with renal compared to without renal involvement was 1.14 (95% CI 0.84-1.56, p=0.406). GPA with renal involvement hospitalizations had a mean increase in adjusted mean LOS of 1.36 days (95% CI 0.82-1.91, p<0.0001) compared to GPA without renal involvement. GPA with renal involvement hospitalizations had an increase in adjusted total hospital charges of $18,723 compared to GPA without renal involvement (95% CI 9,595-27,852, p<0.0001).

Conclusion

There is no statistically significant difference in inpatient mortality for hospitalizations of GPA with and without renal involvement. However, LOS and total hospital charges in GPA with renal involvement were greater than those without renal involvement. Hence GPA with renal involvement has a greater burden to the healthcare system compared to without renal involvement.