Abstract: PO2430
Kidney After Intestinal Transplantation, a Comparison with Combined Kidney with Intestinal Transplant: A UNOS Database Analysis
Session Information
- Clinical and Immunologic Predictors of Post-Transplant Outcomes
October 22, 2020 | Location: On-Demand
Abstract Time: 10:00 AM - 12:00 PM
Category: Transplantation
- 1902 Transplantation: Clinical
Authors
- Yaqub, Muhammad S., Indiana University School of Medicine, Indianapolis, Indiana, United States
- Panezai, Muhammad Ajmal, Indiana University School of Medicine, Indianapolis, Indiana, United States
- Adebiyi, Oluwafisayo O., Indiana University School of Medicine, Indianapolis, Indiana, United States
- Taber, Tim E., Indiana University School of Medicine, Indianapolis, Indiana, United States
- Sharfuddin, Asif A., Indiana University School of Medicine, Indianapolis, Indiana, United States
Background
There is limited data on outcomes for patients receiving a isolated kidney transplant (KAIT) after any prior Multi-organ or Isolated Intestinal transplant (IT). We compared the outcomes of such transplants with Combined Intestinal-Kidney Transplants (CIKT).
Methods
The KT database from 1992 through Sep 2017 was cross-linked with the IT database for all kidney transplants performed. Data was analyzed for incidence, demographics, risk factors and outcomes after KT.
Results
There were a total of 2,886 IT recorded from 1990 through Sep 2017. There were a total of 190 (6.6%) Kidney transplants recorded of which 54 (28.4%) were KAIT while the remaining 136 (71.6%) where Combined (CIKT). The Median Duration from Intestinal Transplant to Kidney transplant was 5.6 years (Range 0.47 to 18.9).One year KAIT graft survival was 87% as compared to CIKT 52%. 5 year graft survival was 74% vs 36%. Death censored KAIT graft survival at 1 year was 98% vs 87% and 5 years 83% vs 74%.overall unadjusted kidney graft survival was significantly lower in CIKT as compared to KAIT p=0.009.
Conclusion
Our data shows that isolated kidney transplant after any prior Multi-organ or isolated Intestinal transplant has higher graft survival as compared to combined Intestinal Kidney Transplant. Higher CNI tough levels may be one common factor leading to lower graft survival.