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Abstract: INFO05

UAB-UCSD O'Brien Center for Acute Kidney Injury (AKI) Research

Session Information

Category: Acute Kidney Injury

  • No subcategory defined


  • Agarwal, Anupam, University of Alabama at Birmigham School of Medicine, Birmingham, Alabama, United States
  • Mehta, Ravindra L., University of California San Diego Medical Center, San Diego, California, United States
  • Sanders, Paul W., University of Alabama at Birmigham School of Medicine, Birmingham, Alabama, United States
  • Andringa, Kelly K., University of Alabama at Birmigham School of Medicine, Birmingham, Alabama, United States

The University of Alabama at Birmingham (UAB)-University of California at San Diego (UCSD) O’Brien Center for AKI (NIH / NIDDK P30 DK079337) has established an interdisciplinary center of excellence in AKI-related research. The main objective of this core center is to provide scientifically rigorous, cost-effective, state-of-the-art methodologies to address questions that will advance our understanding of the pathophysiology, enhance our diagnostic specificity, and expand our preventive and therapeutic approaches for AKI. This objective is implemented in three specific aims: (i) Facilitate hypothesis-driven research through shared core facilities and leverage these core technologies into new projects, interactions and collaborations in AKI-related research, (ii) Foster multidisciplinary interactions among UAB-UCSD investigators and create an extended research base of investigators from multiple institutions at the regional, national and international levels – and (iii) Provide, through the Biomedical Research Cores, a Pilot and Feasibility Program (PAF) and Scientific Enrichment program, the intellectual resources and the research infrastructure, to attract new and established investigators to AKI research.
The core center investigators will benefit from access to a set of three complementary Biomedical Research Cores that will integrate existing intellectual and technological resources of UAB and UCSD and provide a defined set of services that will facilitate the research of investigators pursuing AKI-related basic and clinical research. 1) Core A - Resource for Clinical Studies of AKI (clinical research, comprehensive datasets, biorepository); 2) Core B - Resource for Pre-Clinical Studies of AKI (animal models, small animal imaging and physiology); 3) Core C - Bioanalytical Resource (proteomics, oxidative stress markers, molecular pathology). The Center includes a Biostatistical Resource that provides support to the cores and pilot projects. These cores and the investigator base of clinical and basic investigators will provide unique expertise that is critical for innovative and productive research in AKI to advance our knowledge in this field. Visit us at for details.


  • NIH/NIDDK P30 DK079337