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Kidney Week

Abstract: INFO08

The Kidney Precision Medicine Project (KPMP)

Session Information

Category: CKD (Non-Dialysis)

  • No subcategory defined

Authors

  • Himmelfarb, Jonathan, University of Washington School of Medicine, Seattle, Washington, United States
  • Kretzler, Matthias, University of Michigan Health System, Ann Arbor, Michigan, United States
  • Iyengar, Ravi, Icahn School of Medicine at Mount Sinai, New York, New York, United States

Group or Team Name

  • And the KPMP Consortium
Description

The Kidney Precision Medicine Project (KPMP) is a National Institute of Diabetes and Digestive and Kidney Diseases funded consortium that aims to better understand and treat human kidney diseases. The goals of KPMP are to ethically and safely obtain kidney biopsies from participants with diagnosed acute kidney injury (AKI) or chronic kidney disease (CKD), to find disease subgroups to better stratify kidney disease patients, by identifying critical cells and pathways and targets for novel therapies. The KPMP consortium will create a kidney tissue atlas that can be used to infer and predict pathophysiological states.

Currently, 31 sites make up the consortium, including eight sites that will serve as AKI or CKD recruitment & biopsy centers for the study, and six multi-site tissue interrogation centers that will analyze the biopsy tissues through a combination of imaging, transcriptomic, proteomic and metabolomic technologies. Ten institutions serve as collaborating consortium sites via funding from the KPMP Opportunity Pool. Coordination of study activities is led by several sites in a federated Central Hub. Central Hub responsibilities include administrative organization, data coordination, integration and visualization. Patient engagement is paramount to the work of the consortium; kidney patients advise on study activities by serving on the KPMP Community Engagement Committee, as well as nearly all other consortium committees, including the Steering Committee.

KPMP aims to serve as a publicly available resource to both research and lay communities. The KPMP website www.kpmp.org is a gateway to access all study resources, including protocols and the kidney tissue atlas. Non-identifiable data for the 40 enrolled participants will be made available to the research community immediately after validation at www.atlas.kpmp.org. Controlled access data can be requested by through a KPMP Data Use Agreement with the Central Hub. Funded collaboration opportunities are periodically available through RFAs on the study website.

Funding

  • Funding: KPMP Is supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).