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Kidney Week

Abstract: INFO14

The Indiana O'Brien Center for Advanced Renal Microscopy and Analysis

Session Information

Category: Educational Research

  • No subcategory defined

Authors

  • Dunn, Ken, Indiana University Purdue University at Indianapolis, Indianapolis, Indiana, United States
  • Bacallao, Robert L., Indiana University Purdue University at Indianapolis, Indianapolis, Indiana, United States
  • El-Achkar, Tarek M., Indiana University Purdue University at Indianapolis, Indianapolis, Indiana, United States
  • Molitoris, Bruce A., Indiana University Purdue University at Indianapolis, Indianapolis, Indiana, United States
  • Dagher, Pierre C., Indiana University Purdue University at Indianapolis, Indianapolis, Indiana, United States
Description

The O’Brien Center for Advanced Renal Microscopy and Analysis is based around the Indiana Center for Biological Microscopy in Indianapolis, Indiana and is supported by a partnership with Purdue University. The Center acts as a national resource for investigators to develop and apply state-of-the-art techniques in fluorescence microscopy to understand kidney biology and pathophysiology (http://medicine.iupui.edu/neph/obrien). Our overall goal is to further develop imaging and data processing techniques to offer an integrated microscopy approach to study kidney disease. Thus, we provide renal/urological investigators with a novel set of research methods, quantitative analysis tools, and fluorescent biosensors or probes not available elsewhere to be used in biomedical research, drug discovery, and therapeutic approaches. The Center promotes implementation of the microscopy techniques in kidney research via the Center’s O’Brien Fellows Program, which provides funding to qualified renal investigators supporting short visits (1-2 weeks) to Indianapolis for training and exploratory studies (http://medicine.iupui.edu/neph/obrien/fellow). Visiting investigators are provided with access to microscope and computer systems supporting (1) intravital multiphoton microscopy of rodents (2) large-scale, high-resolution 3D confocal tissue cytometry and (3) CODEX highly-multiplexed tissue cytometry. Members of the OBrien Center interact with visiting investigators to help them design, analyze and interpret imaging results. Investigators are also provided with training in all aspects of microscopy and quantitative image analysis and, depending upon application, methods of sample preparation or the specialized surgical approaches involved in intravital microscopy of rodents.

Funding

  • NIH