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Kidney Week

Abstract: INFO13

The (Re)Building a Kidney (RBK) Project

Session Information

Category: Development, Stem Cells, and Regenerative Medicine

  • No subcategory defined

Author

  • Valerius, M. Todd, Brigham and Women's Hospital Department of Medicine, Boston, Massachusetts, United States

Group or Team Name

  • RBK is supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).
Description

The (Re)Building a Kidney (RBK) project is a National Institute of Diabetes and Digestive and Kidney Diseases funded consortium meant to drive fundamental research of the kidney with goals to create kidney tissue from stem cells, promote the regeneration of nephrons, and develop strategies for engineering therapeutic tissues. RBK projects investigate both development and repair processes in humans and rodent models through transcriptional and proteomic analysis of kidney cell types, bioengineered materials and bioprinting and de-cellularized scaffold approaches, directed differentiation of induced pluripotent stem cells, and human kidney organoid models. These studies further our understanding of the processes of complex organ formation and guide efforts to create kidney tissues in vitro. Through interactions promoted within the consortium, and the addition of new work funded by the consortium each year, the RBK functions as a dynamic and evolving group incorporating new data and ideas continuously and making that work available for the research community through the database and website www.rebuildingakidney.org. Our work has generated detailed differentiation protocols, bulk, single cell and nucleus RNA-seq datasets, and reporter iPS cell lines for live imaging kidney cell populations.

Funding

  • RBK is supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).