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Abstract: PO2194

The Role of Hyperleptinaemia and Low Values of Interleukin 10 in De Novo Donor-Specific Antibody Production After Kidney Transplantation

Session Information

Category: Transplantation

  • 1902 Transplantation: Clinical

Author

  • Dedinska, Ivana, Univerzita Komenskeho v Bratislave Jesseniova lekarska fakulta v Martine, Martin, Slovakia

Group or Team Name

  • Transplant center Martin
Background

White adipose tissue secretes a number of peptide hormones, including leptin, adiponectin, and several cytokines. The aim of this paper was to determine the role of selected adipocytokines (leptin and adiponectin) and interleukins (IL-10 and IL-6) on the development of graft rejection in protocol biopsy after kidney transplantation.

Methods

In a prospective analysis (n=104), we monitored the values of leptin, adiponectin, IL-6, and IL-10 prior to the transplantation and in the 3rd month after the transplantation. The protocol biopsy of the graft was performed in the 3rd month after the transplantation. The group was divided into the following according to the biopsy result: negative result, IFTA 1, borderline, and DSA positive.

Results

After adjusting for the differences in the baseline recipient and donor characteristics, we identified the hyperleptinaemia baseline (HR=2.0444, P=0.0341) and month 3 (HR=49.8043, P<0.0001) as independent risk factors for borderline changes in the protocol biopsy. The hyperleptinaemia baseline (HR=7.4979, P=0.0071) and month 3 (HR=9.7432, P=0.0057) are independent risk factors for de novo DSA positivity. A low value of IL-10 month 3 is a risk factor for de novo DSA positivity (HR=3.0746, P=0.0388).

Conclusion

Higher leptin levels might play a role in rejection and de novo DSA production. We also confirmed the influence of low values of IL-10 on the development of de novo DSA. We assume that values of adipocytokines in context of other risk factors can predict the immunological risk of patients after kidney transplantation.

ROC curve. Leptin 3M and IL-10 3M for the endpoint of de novo DSA and borderline

Funding

  • Government Support – Non-U.S.