Abstract: PO0802
Dialysis Adequacy and Risk of Dementia in Elderly Hemodialysis Patients
Session Information
- Dialysis Care: Epidemiology and the Patient Experience
November 04, 2021 | Location: On-Demand, Virtual Only
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 701 Dialysis: Hemodialysis and Frequent Dialysis
Authors
- Kim, Hyung Woo, Yonsei University College of Medicine, Seodaemun-gu, Seoul, Korea (the Republic of)
- Jhee, Jong Hyun, Yonsei University College of Medicine, Seodaemun-gu, Korea (the Republic of)
- Joo, Young Su, Yonsei University College of Medicine, Seodaemun-gu, Korea (the Republic of)
- Yang, Ki Hwa, Health Insurance Review and Assessment Service, Wonju, Korea (the Republic of)
- Jung, Jin Ju, Health Insurance Review and Assessment Service, Wonju, Korea (the Republic of)
- Shin, Ji Hyeon, Health Insurance Review and Assessment Service, Wonju, Korea (the Republic of)
- Han, Seung Hyeok, Yonsei University College of Medicine, Seodaemun-gu, Seoul, Korea (the Republic of)
- Yoo, Tae-Hyun, Yonsei University College of Medicine, Seodaemun-gu, Seoul, Korea (the Republic of)
- Kang, Shin-Wook, Yonsei University College of Medicine, Seodaemun-gu, Seoul, Korea (the Republic of)
- Park, Jung Tak, Yonsei University College of Medicine, Seodaemun-gu, Seoul, Korea (the Republic of)
Background
Dementia is prevalent among elderly patients undergoing hemodialysis. However, the association between dialysis adequacy and the risk of dementia is uncertain.
Methods
A total of 10,567 patients aged >65 years undergoing maintenance hemodialysis who participated in a national hemodialysis quality assessment program were analyzed. The patients were classified into quartile groups based on single-pool Kt/V levels. The associations between single-pool Kt/V and the development of dementia, Alzheimer’s disease (AD), and vascular dementia (VD) were examined.
Results
The mean age of the patients was 72.9 years, and 43.4% were female. The mean baseline single-pool Kt/V level was 1.6 ± 0.3. During a median follow-up of 45.6 (45.6–69.9) months, there were 27.6, 23.9, and 2.8 events/1000 person-years of overall dementia, AD, and VD, respectively. The incidences of overall dementia, AD, and VD were lowest in the highest single-pool Kt/V quartile group. Compared with the lowest single-pool Kt/V quartile, the risks of incident overall dementia and AD were significantly lower in the highest quartile (sub-distribution hazard ratio [sHR]: 0.69, 95% confidence interval [CI]: 0.58–0.82 for overall dementia; sHR: 0.69, 95% CI: 0.57–0.84 for AD). Inverse relationships were found between the risks of developing overall dementia and AD, and single-pool Kt/V. However, no significant relationship was observed between single-pool Kt/V levels and VD development.
Conclusion
Increased dialysis clearance was associated with a lower risk of developing dementia in elderly hemodialysis patients.