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Kidney Week

Abstract: PO1579

Clinical Outcomes of Kidney Diseases Diagnosed in Active Duty Service Members

Session Information

Category: Glomerular Diseases

  • 1203 Glomerular Diseases: Clinical, Outcomes, and Trials

Authors

  • Tobin, Trevor Wesley, Walter Reed National Military Medical Center, Bethesda, Maryland, United States
  • Thurlow, John Stephen, Walter Reed National Military Medical Center, Bethesda, Maryland, United States
  • Nee, Robert, Walter Reed National Military Medical Center, Bethesda, Maryland, United States
  • Yuan, Christina M., Walter Reed National Military Medical Center, Bethesda, Maryland, United States
Background

There are no studies that have reported glomerular disease prevalence and looked at the overall healthcare outcomes following renal biopsies in active duty soldiers. We aimed to determine the prevalence of renal diseases amongst the soldiers biopsied at out hospital and determine the outcomes for these individuals as a result of their diagnoses.

Methods

In this retrospective study, we evaluated the results of all native renal biopsies performed at Walter Reed National Military Medical Center from 2005 to 2020. We used this data to determine the prevalence of patients who progressed to have ESKD (End Stage Kidney Disease), renal transplantation, creatinine doubling, proteinuria greater than 3.5 grams/day, medical evaluation board (MEB), and death. The AHLTA and JLV EMR systems were used to collect data on the patients who met our inclusion criteria. After the data was collected, chi squared tests were performed and Kaplan Meier Curves were created for analysis.

Results

Among 169 patients (mean age =32 years old; 79% male; 48% white; 37% black; 7% Hispanic; 4% Asian; 3% pacific islander; 2% other), the most common indication for renal biopsy was for concomitant hematuria and proteinuria (31%) and the most common histologic diagnosis was IgA Nephropathy (23%). The mean time of follow up was 7.3 years. 11% progressed to ESKD, of whom 87% received a kidney transplant (10% overall). Approximately one third progressed to proteinuria greater than 3.5 grams per day and 5% died.

Conclusion

We identified IgA Nephropathy as the dominant histologic diagnosis in our patients undergoing renal biopsy between 2005 and 2020. Despite our patients being largely young and healthy individuals, renal biopsy identified severe disease with over 10% of patients progressing to ESKD and 5% mortality.