Kidney Week

Abstract: PO1973

Narrow Range of Plant-Protein Intake in the CKiD Cohort Does Not Demonstrate Changes in Estimated GFR

Session Information

• Pediatric Nephrology: AKI, Dialysis, Transplant, CKD, and Nephrotic Syndrome
  November 04, 2021 | Location: On-Demand, Virtual Only
  Abstract Time: 10:00 AM - 12:00 PM

Category: Pediatric Nephrology

• 1700 Pediatric Nephrology

Authors

• Shah, Lokesh N., Stanford University School of Medicine, Stanford, California, United States

Lokesh N. Shah, MD

• Matheson, Matthew, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, United States

Matthew Matheson,

• Furth, Susan L., The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States

Susan L. Furth,

• Schwartz, George J., University of Rochester Medical Center, Rochester, New York, United States

George J. Schwartz,

• Warady, Bradley A., University of Missouri Kansas City School of Medicine, Kansas City, Missouri, United States

Bradley A. Warady,

• Wong, Cynthia, Stanford University School of Medicine, Stanford, California, United States

Cynthia Wong,

Background

Vegetable or plant-based sources of protein may confer health benefits in children with progressive kidney disease. There is currently a knowledge gap in understanding the effect of different proportions of vegetable-based proteins on CKD progression in children.

Methods

The CKiD study is a multicenter, observational cohort of children with CKD. The Child Harvard Service Food Frequency Questionnaire (HSFFQ) was used to assess dietary intake. The proportion of vegetable protein (VP%) was defined as the fraction of plant protein to total protein intake. Statistical analysis used a mixed model with random intercept and slope to determine the effect on log-transformed changes in estimated GFR.

Results

This dataset included 2000 records on 631 subjects with a baseline eGFR from 30 to 90 mL/min/1.73m² calculated using CKiD Creatinine–Cystatin C 2012 formula. Across all dichotomized groups of children (sex, African American race, Hispanic ethnicity, etiology of CKD, hypertension, anemia, hyperkalemia, hyperphosphatemia, acidosis, BMI < 95^th percentile) the median VP% was 32-35% regardless of group. Longitudinal mixed model analysis did not show any effect on eGFR due to changes in VP%.

Conclusion

Children with chronic kidney disease obtain about a third of their protein intake from plant or vegetable-based sources. More than 90% children in the CKiD cohort had a VP% that was less than 50% of total protein intake. Due to the narrow homogeneity of dietary patterns, there was no effect on the change in eGFR with changes in VP%.

Funding

• NIDDK Support