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Abstract: PO2276

Kidney Disease and Longitudinal Changes in Muscle Strength in Older Adults

Session Information

Category: CKD (Non-Dialysis)

  • 2101 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

  • Schrauben, Sarah J., University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States
  • Lange-Maia, Brittney S., Rush University Medical Center, Chicago, Illinois, United States
  • Fried, Linda F., University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States
  • Newman, Anne B., University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, United States
  • Sarnak, Mark J., Tufts Medical Center, Boston, Massachusetts, United States
Background

Persons with chronic kidney disease (CKD) experience lower physical function and increased risk of disability, both of which have strong prognostic importance for poor clinical outcomes. To date, functional status studies in populations with CKD have focused on physical activity and/or individuals with end-stage kidney disease, and have largely neglected measures of muscle strength, especially among those with non-dialysis dependent CKD.

Methods

Participants were from the Health, Aging and Body Composition Study, a longitudinal cohort focused on functional decline in adults aged 70-79 years at baseline. Kidney function was defined by estimated glomerular filtration rate (eGFR) using the CKD-EPI Cystatin C Equation at each available visit (up to 5) during 10 years of follow up. Participants were grouped based upon their longitudinal eGFR: no CKD (eGFR ≥60 mL/min/1.73 m2), prevalent CKD (baseline eGFR <60 mL/min/1.73 m2), and incident CKD (baseline eGFR ≥60 but <60 mL/min/1.73 m2 during follow up). Grip and quadriceps strength were also assessed longitudinally (8 and 6 visits, respectively). Linear mixed models stratified by sex tested associations between kidney function groups and grip and quadriceps strength over time.

Results

Of the 2,630 participants with median age 73 years, 64.9% had no CKD, 23.4% had prevalent CKD, and 11.7% developed incident CKD. At baseline, men and women without CKD had higher unadjusted grip and quadriceps strength compared to those with CKD. In adjusted linear mixed models for grip strength, men with CKD had faster decline over time, compared to men without CKD (Table). For women, changes in grip strength were not different across kidney function groups. In adjusted models of quadriceps strength over time, there were no differences among kidney function groups.

Conclusion

Men with CKD had faster decline in grip strength compared to those without CKD. Future studies can determine if recognizing decreased muscle strength and intervening can change this functional trajectory among those with CKD.

Funding

  • NIDDK Support