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Abstract: PO0098

Anxiety in Patients with CKD During the COVID-19 Pandemic: Predictors and Consequences Among Chronic Renal Insufficiency Cohort (CRIC) Study Participants

Session Information

Category: Coronavirus (COVID-19)

  • 000 Coronavirus (COVID-19)


  • Dorans, Kirsten S., Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, United States
  • Wright Nunes, Julie A., University of Michigan Medical School, Ann Arbor, Michigan, United States
  • Schaubel, Douglas Earl, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States
  • Sha, Daohang, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States
  • Rahman, Mahboob, Case Western Reserve University, Cleveland, Ohio, United States
  • Feldman, Harold I., University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States

Group or Team Name

  • CRIC Study Investigators

Chronic kidney disease (CKD) is associated with anxiety and depression. Though the Coronavirus 2019 (COVID-19) pandemic has increased stressors on patients with CKD, assessments of anxiety, its predictors and consequences, including on virus mitigation behaviors are lacking.


From June to October 2020, we administered a survey about anxiety related to the COVID-19 pandemic to 1888 participants in CRIC. We examined associations of anxiety with demographics, clinical indices, health literacy, health-related behaviors and COVID-19 mitigation behaviors.


Four anxiety-related constructs were assessed: one composite overall global anxiety construct and three sub-constructs: general anxiety, worry, mood/feelings. Construct scores had moderate to strong correlations with each other (0.48–0.89) and high internal consistency (Cronbach’s alpha ≥0.81). In adjusted analyses, younger age, female gender, Hispanic ethnicity, cardiovascular disease, household income <$100,000, unemployment, and marginal or inadequate health literacy predicted higher anxiety. During the pandemic, higher global anxiety scores were associated with higher odds of eating less healthy foods, reduced physical activity, and weight gain as well as reporting always wearing a mask in public in the past week.


Several factors predict higher anxiety related to the COVID-19 pandemic. Although anxiety is typically thought to be an undesired outcome, in addition to being associated with less healthy behaviors, anxiety was associated with higher self-reported mask wearing. Our study indicates a need for interventions to support healthy behaviors and virus mitigation strategies, without provoking or worsening anxiety in patients with CKD.

Multivariable-adjusted logistic regression examining associations between overall anxiety composite score and self-reported behaviors.
 Odds Ratiop value
In past week, always wear a mask in public1.27<0.001
In past week, always remain ≥6 feet apart from others not in household while in public1.060.26
Since pandemic began, travel out of state/country0.940.43
Eating less healthy during pandemic vs eating the same or healthier during the pandemic1.27<0.001
Less physically active during pandemic vs having the same or higher level of physical activity1.33<0.001
Weight gain during the pandemic vs maintaining or losing weight1.21<0.001


  • NIDDK Support