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Abstract: PO2279

Serum Uric Acid Levels and Nephrosclerosis in a Population-Based Autopsy Study: The Hisayama Study

Session Information

Category: CKD (Non-Dialysis)

  • 2101 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

  • Maki, Kenji, Kyushu Daigaku Igakubu Daigakuin Igakukei Gakufu Daigakuin Igaku Kenkyuin, Fukuoka, Japan
  • Hata, Jun, Kyushu Daigaku Igakubu Daigakuin Igakukei Gakufu Daigakuin Igaku Kenkyuin, Fukuoka, Japan
  • Sakata, Satoko, Kyushu Daigaku Igakubu Daigakuin Igakukei Gakufu Daigakuin Igaku Kenkyuin, Fukuoka, Japan
  • Furuta, Yoshihiko, Kyushu Daigaku Igakubu Daigakuin Igakukei Gakufu Daigakuin Igaku Kenkyuin, Fukuoka, Japan
  • Oishi, Emi, Kyushu Daigaku Igakubu Daigakuin Igakukei Gakufu Daigakuin Igaku Kenkyuin, Fukuoka, Japan
  • Nakano, Toshiaki, Kyushu Daigaku Igakubu Daigakuin Igakukei Gakufu Daigakuin Igaku Kenkyuin, Fukuoka, Japan
  • Oda, Yoshinao, Kyushu Daigaku Igakubu Daigakuin Igakukei Gakufu Daigakuin Igaku Kenkyuin, Fukuoka, Japan
  • Kitazono, Takanari, Kyushu Daigaku Igakubu Daigakuin Igakukei Gakufu Daigakuin Igaku Kenkyuin, Fukuoka, Japan
  • Ninomiya, Toshiharu, Kyushu Daigaku Igakubu Daigakuin Igakukei Gakufu Daigakuin Igaku Kenkyuin, Fukuoka, Japan
Background

The information regarding the influence of serum uric acid levels on the pathological changes in kidney is limited. We aimed to examine the association between serum uric acid levels and pathological findings of nephrosclerosis in population-based autopsy samples.

Methods

A total of 923 deceased subjects in a Japanese community underwent autopsy examinations between 1974 and 1994. Of these, 547 cases with available kidney tissues and health examinations data within a median of 3 years before death were eligible for the present study. Serum uric acid levels were categorized into quintiles (Q1, 1.8-3.9; Q2, 4.0-4.6; Q3, 4.7-5.4; Q4, 5.5-6.3; Q5, 6.4-12.7 mg/dL). The presence of the advanced degree of glomerular sclerosis, kidney arteriolar hyalinosis, and kidney arteriosclerosis were determined by the 90th percentile or more of a glomerular sclerosis index and an arteriolar hyalinosis index, and the 10th percentile or less of a wall-lumen ratio, respectively. A logistic regression model was used to evaluate odds ratios and their 95% confidence intervals of serum uric acid levels on each kidney lesions.

Results

Higher serum uric acid levels were associated significantly with greater age- and sex-adjusted glomerular sclerosis index and lesser wall-lumen ratio. Subjects in the Q5 groups had a significantly greater likelihood of advanced glomerular sclerosis and advanced kidney arteriosclerosis than in subjects in the Q1 group after adjusting for potential covariates. There was no evidence of significant associations of serum uric acid levels with arteriolar hyalinosis index and the presence of advanced arteriolar hyalinosis.

Conclusion

Elevated serum uric acid levels were associated significantly with advanced glomerular sclerosis and advanced kidney arteriosclerosis, but not with advanced arteriolar hyalinosis in community based autopsied samples of Japanese.