ASN's Mission

To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005

email@asn-online.org

202-640-4660

The Latest on X

Kidney Week

Please note that you are viewing an archived section from 2021 and some content may be unavailable. To unlock all content for 2021, please visit the archives.

Abstract: PO0224

Evaluation of Chosen Biochemical Parameters in Diagnosis of AKI in Course of Burn Disease

Session Information

Category: Acute Kidney Injury

  • 101 AKI: Epidemiology, Risk Factors, and Prevention

Authors

  • Klimm, Wojciech, Wojskowy Instytut Mediczny, Warszawa, Mazowieckie, Poland
  • Szamotulska, Katarzyna, Instytut Matki i Dziecka, Warszawa, Poland
  • Wozniak-Kosek, Agnieszka, Wojskowy Instytut Mediczny, Warszawa, Mazowieckie, Poland
  • Niemczyk, Stanislaw, Wojskowy Instytut Mediczny, Warszawa, Mazowieckie, Poland
Background

Burn disease after severe thermal injury often causes multi-organ damage, included AKI. Diagnosis of AKI based on standard renal biomarkers seems to be not optimum, because of its too late beginning. The aim of the study is evaluation of non-renal biochemical parameters as early prognostic factors of AKI in this group of patiens (pts).

Methods

33 adult pts; 11(33,3%) females, 33(66,7%) males; were hospitalised after severe burn injury. Mean age was 48,3(±18,8) years. None of the pts presented symptoms of chronic kidney disease. Biochemical parameters - platelets count (PLT); serum concentration of albumin (ALB), sodium (Na), potassium (K), urea (U), creatinine (Cr); glomerular filtration ratio (GFR), serum activity of asparagine transaminase (AST) and creatine phosphokinase (CK); blood gas tests and urine sodium excretion - were measured at each patient once daily till 7thday. The results were presented as a mean value with standard deviation or median with interquartile range. AKI criteria were based on RIFLE/AKIN scale. Relationship between parameters and AKI risk were analysed with chi-square test and presented as relative risk (RR) with 95% confidence level, p-value significant level was <0,5.

Results

Biochemical symptoms of AKI were confirmed in 15 (60,6%) pts. AKI developed at the beginning of hospitalisation, on the1st day – 10 (30,3%) pts and 2rd day – 4 (12,1%) pts. Non-normative levels of biomarkers were reported in the same time: low PLT count - average 91,6(±42,7) x10^9/l in 5 (15%) pts; low ALB concentration – avg. 2,4(±0,7) g/dl in 32 (97%) pts; high K concentration – avg. 6,1(±0,7) mmol/l in 14 (42,4%) pts; high activity of AST – avg. 73(40,5÷141,5) U/l in 21(63,6%) pts and CK – avg. 429,0(242,0÷4720,0) U/l in 21 (63,6%) pts and metabolic acidosis with low pH - avg. 7,22(±0,08) in 19 (57,6)%, pts. The significant relationship between parameters and the risk of AKI was confirmed: high activity of CK (RR 2,86; p=0,047) and AST (RR 2,73; p=0,034), and low concentration of ALB (RR 2,63; p=0,012).

Conclusion

AKI is a frequent and important problem in burned patients, occurred in the first days after injury as a part of multi-organ dysfunction. Non-renal biochemical parameters as serum concentration of ALB, activity of CK and AST can be useful early biomarkers of AKI after massive burn injury.