Abstract: PO1009
The Association Between Lower Serum Potassium Level and Increased Cardiovascular Death Among Patients Undergoing Peritoneal Dialysis
Session Information
- Peritoneal Dialysis
November 04, 2021 | Location: On-Demand, Virtual Only
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 702 Dialysis: Home Dialysis and Peritoneal Dialysis
Authors
- Tsujikawa, Hiroaki, Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, Fukuoka, Fukuoka, Japan
- Nakano, Toshiaki, Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, Fukuoka, Fukuoka, Japan
- Ohnaka, Shotaro, Tagawa Shiritsu Byoin, Tagawa, Fukuoka, Japan
- Yamada, Shunsuke, Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, Fukuoka, Fukuoka, Japan
- Tsuruya, Kazuhiko, Nara Kenritsu Ika Daigaku Yakurigaku Kyoshitsu, Kashihara, Nara, Japan
- Torisu, Kumiko, Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, Fukuoka, Fukuoka, Japan
- Kanai, Hidetoshi, Kokura Kinen Byoin, Kitakyushu, Fukuoka, Japan
- Kitazono, Takanari, Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, Fukuoka, Fukuoka, Japan
Background
In patients undergoing peritoneal dialysis (PD), lower serum potassium concentration has been related to low nutrition status and suggested as a risk factor for all-cause and cardiovascular mortality. However, the risk of lower serum potassium concentration for cardiovascular death in patients using renin-angiotensin system (RAS) inhibitors or β-blockers is not clear. This study investigated the relationship between lower serum potassium concentration and cardiovascular death among Japanese patients undergoing PD.
Methods
We retrospectively included the 549 patients from our previous multicenter cohort study (Fukuoka Peritoneal Dialysis Database Study). The participants who had undergone PD for at least 90 days were registered from 1 January 2006 to 31 December 2016 and followed until they were transferred to hemodialysis, received a kidney transplantation, died during PD, or were lost to follow-up, or until 31 December 2017. The patients were divided into three groups according to the baseline serum potassium concentration (T1 ≤ 4.0, 4.0 <T2 ≤ 4.5, T3> 4.5 mEq/L). We estimated the relationship between serum potassium concentration and cardiovascular mortality using a Cox proportional hazards model.
Results
During the median observation period of 2.3 years, 111 patients died of any cause, and 38 died of cardiovascular. After multivariable adjustment in the Cox proportional hazard model, lower serum potassium concentration was shown to be an independent risk factor for cardiovascular death; (hazard ratio 95% confidence intervals) T2 and T1 vs. T3 were 2.21 (0.77–6.27) and 2.67 (1.01–7.07), respectively. Stratified-analysis according to the use of RAS inhibitors, β-blockers, or a combination of both drugs showed that this relation was not modified by the use of these drugs.
Conclusion
This study showed that lower serum potassium concentration was associated with increased cardiovascular mortality in PD patients. There was no difference in the risk of lower serum potassium concentration for cardiovascular death according to the use of the RAS inhibitors and/or β-blockers in PD patients.