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Abstract: PO1576

Clinicopathological Characteristics of Adult IgA Nephropathy: A Retrospective Cohort Study

Session Information

Category: Glomerular Diseases

  • 1203 Glomerular Diseases: Clinical, Outcomes, and Trials

Authors

  • Caster, Dawn J., University of Louisville, Louisville, Kentucky, United States
  • Abner, Clint, Arkana Laboratories, Little Rock, Arkansas, United States
  • Ararat, Kerime, Arkana Laboratories, Little Rock, Arkansas, United States
  • Walker, Patrick D., Arkana Laboratories, Little Rock, Arkansas, United States
  • Yakubu, Amin, Genesis Research, LLC, Hoboken, New Jersey, United States
  • Bunke, Martin C., Travere Therapeutics Inc, San Diego, California, United States
Background

IgA nephropathy (IgAN) is the most common form of primary glomerular nephropathy and a leading cause of chronic kidney disease (CKD). These analyses characterize clinical and histological features of IgAN in adults at time of kidney biopsy.

Methods

A retrospective study of clinical and histologic characteristics was performed in patients (pts) ≥18 yrs of age with ≥1 IgAN positive kidney biopsy without prior kidney transplant reported from Arkana Laboratories (Jan 1, 2016-May 30, 2020). Estimated glomerular filtration rate (eGFR) was calculated using the CKD-Epi equation without race modifier. All results are at the time of biopsy.

Results

Of 67,262 kidney biopsies performed during the study period, 4,384 (6.5%) IgAN positive cases met the study criteria and were included, of which, 62.7% were male, 49.6% White, 5.1% African American, 5.3% Hispanic, 5.6% Asian and 34.4% Unknown/Other race/ethnicity. Mean (SD) age at biopsy was 47.7 (16.6) yrs. Urine protein to creatinine ratio/ 24-hour urine protein data were available for 52.4% of pts and the median (Q1-Q3) was 3.0 (1.0 – 5.0) g/g. Additionally, 65.2% of pts had hypertension, 63.1% had known hematuria, 25.7% had severe arteriosclerosis, 15.8% had severe arteriolosclerosis, and 27.2% and 20.9% of patients had CKD stage 3 and 4, respectively. The mean (SD) eGFR was 42.4 (32.1) mL/min/1.73m2. Immunofluorescence, sclerosis, and fibrosis characteristics are presented in Table 1.

Conclusion

The large proportion of pts diagnosed at CKD stage ≥3 and high MEST-C scores for S and T suggest significant disease duration at the time of biopsy. Earlier intervention may be of value to prevent ESKD.

Funding

  • Commercial Support