ASN's Mission

ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005

email@asn-online.org

202-640-4660

The Latest on Twitter

Kidney Week

Abstract: PO1752

Effects of Home BP-Based Behavioral Guidance on Urinary Albumin Excretion in School Workers with Microalbuminuria-Miyagi Karoshi Prevention Study

Session Information

Category: Health Maintenance, Nutrition, and Metabolism

  • 1300 Health Maintenance, Nutrition, and Metabolism

Authors

  • Munakata, Masanori, Tohoku Rosai Byoin, Sendai, Miyagi, Japan
  • Hattori, Tomomi, Tohoku Rosai Byoin, Sendai, Miyagi, Japan
  • Kubota-Nakayama, Fumie, Tohoku Rosai Byoin, Sendai, Miyagi, Japan
  • Konno, Satoshi, Tohoku Rosai Byoin, Sendai, Miyagi, Japan
  • Inoue, Nobutaka, Kobe Rosai Byoin, Kobe, Hyogo, Japan
  • Nakamura, Tomohiro, Tohoku Medical Megabank Organization, Sendai, Japan
  • Hozawa, Atsushi, Tohoku Medical Megabank Organization, Sendai, Japan
Background

Prevention of work-related cardiovascular events, or Karoshi is an important social issue in Japan.This study aimed to examine if home-BP based behavioral guidance is effective to reduce CV event risk in school staffs associated with microalbuminuria, a marker of endothelial damage.

Methods

Subjects were 3868 Miyagi prefectural school workers . Urinary albumin excretion adjusted for creatinine (UAE) and daily sodium intake based on Tanaka method were examined together with usual annual health check-up in 2019. Among them, 169 were diagnosed as having microalbuminuria (30-299.9mg/gCr). Ninety-one subjects agreed to receive the home-BP based health guidance. Guidance was given according to 5 days mean of home BP measurements, or encouraging medical consultation and lifestyle guidance for subjects with ≧135/85mmHg, lifestyle guidance for subjects with 125-134/80-84mmHg and adequate lifestyle guidance for subjects <125/80mmHg if necessary. Outcomes were UAE and frequency of microalbuminuria in the next year. Data were compared between guided and non-guided subjects. Subjects with menstruation were excluded from analysis. Final analysis number was 48 and 43 for guided and non-guided groups.

Results

Guided group demonstrated similar baseline data as compared with non-guided group for age, male gender, body mass index, cardiovascular risk factors and UAE level. Prescription rate for hypertension and diabetes also was similar between them. LogUAE was significantly and similarly decreased in both groups. One year later, microalbuminuria was present in 31.2% for guided group and 30.2% for non-guided group (n.s.). Systolic BP was lowered significantly as compared with baseline in the guided group but not in non-guided group. HbA1C level and daily sodium intake were increased as compared with baseline in guided group but not in non-guided group. Sensitivity analysis excluding treated patients for hypertension or diabetes from baseline demonstrated essentially similar results.

Conclusion

Reduction in UAE did not differ between groups with or without home-BP based behavioral guidance. Our data suggest that notification of microalbuminuria per se have considerable degree of favorable behavioral effects in school workers with microalbuminuria.

Funding

  • Government Support – Non-U.S.