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Abstract: PO0942

Validation of Urea Removal in Novel Sorbent Dialysis System

Session Information

Category: Dialysis

  • 701 Dialysis: Hemodialysis and Frequent Dialysis

Authors

  • Borrillo, Brandon D., Diality Inc, Irvine, California, United States
  • Chen, Tzu Tung, Diality Inc, Irvine, California, United States
  • Khawar, Osman, Diality Inc, Irvine, California, United States
  • Poppe, Clayton, Diality Inc, Irvine, California, United States
Background

The Diality Hemodialysis Machine will provide a range of hemodialysis modalities to expand the population of patients that may benefit from hemodialysis. One modality uses a sorbent filter that will accommodate the decentralization of dialysis delivery.

Specific Aims: To assess urea mass removal during a simulated dialysis utilizing a novel sorbent filter.

Methods

Nine simulated dialysis sessions were conducted utilizing between 50L and 125L volumes of dialysate circulated at approx. 400 mL / min & 37 C through a sorbent cartridge with a standard dialysate. (Table 1) It is expected that with each pass through the filter the dialysate urea mass will decline. The experiment is continued until breakthrough occurs or the infusate outlet reaches 10 ppm of NH4. A solution containing K, Ca and Mg salts were constantly infused to replenish electrolytes lost in each pass. Another solution was infused at a variable rate as determined by conductivity to maintain Na Balance.

Results

The results are provided in table 1. The average URR was 63.8 % ranging from 53.3 to 87.0 %. The average starting BUN was 48.2 mg/dL and the average ending BUN was 16.8 mg/dL.

Conclusion

The initial experiments using a sorbent filter demonstrate a URR of near 65 is feasible. Future design changes will be scaled to handle larger amounts of urea and provide acceptable clearances.

Table 1:
Start BUN (mg/dl)End BUN (mg/dL)URRCirculation Volume (L)Breakthrough (mins)
42.019.653.3125225
42.020.252.0125242
42.016.261.3125265
42.016.860.0125262
56.07.387.050249
42.018.855.350232
56.023.258.575229
70.017.674.875242
42.011.872.075229

Funding

  • Commercial Support