Abstract: PO2277
Health-Related Quality of Life in Patients with Inflammation and Non-Dialysis-Dependent CKD
Session Information
- CKD: Associations and Electrolytes
November 04, 2021 | Location: On-Demand, Virtual Only
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2101 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention
Authors
- Lai, Rachel, FibroGen Inc, San Francisco, California, United States
- Szczech, Lynda, FibroGen Inc, San Francisco, California, United States
- Clayton, Sarah, Adelphi Group Ltd, Bollington, Cheshire East, United Kingdom
- Harrison, Lewis, Adelphi Group Ltd, Bollington, Cheshire East, United Kingdom
- Lowe, Mollie, Adelphi Group Ltd, Bollington, Cheshire East, United Kingdom
- Jackson, James, Adelphi Group Ltd, Bollington, Cheshire East, United Kingdom
Background
Inflammation is common in chronic kidney disease (CKD) and can affect treatment of anemia, which is a common complication of CKD. Both inflammation and anemia in CKD have been linked with poor health-related quality of life (HRQoL), though evidence is limited. We aimed to assess the association between inflammation and HRQoL in patients with non-dialysis-dependent CKD (NDD-CKD).
Methods
Data were drawn from the Adelphi CKD Disease Specific Programme™, a point-in-time survey of physicians and their patients with CKD (stage 3-5D) collected in the United States in 2018. Patients were also invited to complete a questionnaire which included subjective assessment of the impact of CKD, as well as the Kidney Disease Quality of Life-36 questionnaire (KDQoL-36). Patients with NDD-CKD who filled out the KDQoL-36 were included in this analysis. Inflammation was defined as C-reactive protein ≥4.9 mg/L, ferritin ≥700 ng/mL, or albumin ≤3.6 g/L. T-tests were conducted to assess differences in KDQoL-36 scores between patients with and without inflammation.
Results
Inflammation was present in 136/491 (28%) patients. Mean KDQoL-36 scores reported by patients with inflammation were lower than scores reported by patients without inflammation across all 5 domains (all p<0.05; Table 1). Most differences in KDQoL scores between patients with and without inflammation exceeded the distribution-based minimal clinically important difference (MCID).
Conclusion
We found that patients with inflammation in NDD-CKD reported poorer HRQoL compared with those without. Reducing inflammation in CKD may improve HRQoL.
Funding
- Commercial Support –