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Abstract: PO0920

Validation of Automated Sodium Control in a Novel Dialysis System

Session Information

Category: Dialysis

  • 701 Dialysis: Hemodialysis and Frequent Dialysis

Authors

  • Borrillo, Brandon D., Diality Inc, Irvine, California, United States
  • Chen, Tzu Tung, Diality Inc, Irvine, California, United States
  • Khawar, Osman, Diality Inc, Irvine, California, United States
  • Poppe, Clayton, Diality Inc, Irvine, California, United States
Background

The Diality Hemodialysis Machine will provide a range of hemodialysis modalities to expand the population of patients that may benefit from hemodialysis. One modality uses a sorbent filter that will accommodate the decentralization of dialysis delivery.

Specific Aims: To test an automated feedback program designed to regulate the infusion of an alkali needed to maintain proper sodium concentration in a dialysate solution

Methods

A 125L volume of simulated dialysis was circulated at ~400 mL/min and ~37 C through a sorbent cartridge which removed the urea from the solution. The fluid exiting the cartridge had no Ca, Mg or K. These chemicals were reinfused through a pump in a solution containing Ca, K and Mg salts. A conductivity sensor (cond) was used in a feedback control of the alkali infusion pump. The feedback control adjusted the pump flow rate to maintain the conductivity of the infusate at 14.0 mS/cm. The sensor was programmed from a curve model of the alkali over time from previous experiments. Occasional spikes of Na+ were added to test the feedback control. The experiment ran until a NH4 reached 10ppm which defined filter breakthrough.

Results

The results are depicted in table 1. TP1, the mean sodium concentration [Na] in the dialysate at pump 1, after mixing in a 125L tank was in the range139.8 – 141.7 mEq/L. TP2, the mean dialysate [Na] at pump 2 after leaving the sorbent filter was 124.2 (+/-2.4) mEq/L. This correlates with cond1 and was 12.8 (+/- 0.4) mS/cm. TP3, the mean dialysate [Na] after being replenished with the alkali solution immediately prior entering the tank for remixing was 139.5 (+/- 1.9) mEq/L and correlated with cond2 of 14.1 mS/cm).

Conclusion

The results validate the accuracy of the conductivity sensor in correctly regulating the alkali infusate.

Funding

  • Commercial Support