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Abstract: PO2262

Ideal Cardiovascular Health and Risk for Incident CKD: Findings from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Session Information

Category: CKD (Non-Dialysis)

  • 2101 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

  • Viamontes, Christopher George, University of Illinois at Chicago College of Medicine, Chicago, Illinois, United States
  • Ricardo, Ana C., University of Illinois Hospital and Health Sciences System, Chicago, Illinois, United States
  • Chen, Jinsong, University of Illinois Hospital and Health Sciences System, Chicago, Illinois, United States
  • Cai, Jianwen, University of North Carolina System, Chapel Hill, North Carolina, United States
  • Gonzalez, Hector M., University of California San Diego, La Jolla, California, United States
  • Yunes, Milagros, Montefiore Medical Center, Bronx, New York, United States
  • Tarraf, Wassim H., Wayne State University School of Medicine, Detroit, Michigan, United States
  • Lash, James P., University of Illinois Hospital and Health Sciences System, Chicago, Illinois, United States
Background

Prior studies have reported that measures of ideal cardiovascular health influence the risk of developing chronic kidney disease (CKD). However, U.S. Hispanic/Latino adults were not well represented in these studies.

Methods

We analyzed data from 8,770 U.S. Hispanic/Latino adults aged 18-64 years enrolled in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) who completed a baseline (2008-2011) and a follow-up (2014-2017) visit and did not have CKD at baseline (estimated glomerular filtration rate [eGFR] ≥ 60 ml/min/1.73m2 and urine albumin-to-creatinine ratio [UACR] <30 mg/g). Cardiovascular health metrics were assessed using the American Heart Association’s Life’s Simple 7 (LS7, nonsmoker; body mass index <25 kg/m2; ≥150 minutes/week of physical activity; healthy diet; total cholesterol <200 mg/dL; blood pressure <120/80 mm Hg; and fasting blood glucose <100 mg/dL). Outcomes included incident ACR (defined as UACR ≥30 mg/g) and incident low eGFR (defined as eGFR <60 ml/min/1.73m2 and a decline in eGFR ≥1 ml/min per year). The association between LS7 and the outcomes was evaluated using Poisson regression with robust variance while accounting for the complex sampling design of HCHS/SOL.

Results

At baseline, the weighted mean age was 42.1 years, 56.3% were female, mean eGFR was 107 ml/min/1.73 m2, median UACR was 7 mg/g, and 49% had ≥4 ideal health factors. After a median follow-up of 5.9 years, there were 598 incident albuminuria events, and 201 low eGFR events. Compared with the presence of <4 ideal factors, ≥4 ideal health factors was associated with lower risk for incident albuminuria but there was no association with incident low eGFR (Table).

Conclusion

Among U.S. Hispanic/Latino adults, the presence of a higher number of ideal health factors was associated with a lower risk of incident albuminuria. These findings may have implications for public health strategies for CKD prevention in this population.

OutcomeNumber of Ideal FactorsRate per 1000 Person YearsIncident Density Radio (95% CI)
Incident Albuminuria< 414.5 (13.2, 16.0)Referent
≥ 47.6 (6.6, 8.8)0.62 (0.46, 0.85)
Incident Low eGFR< 45.5 (4.7, 6.5)Referent
≥ 41.8 (1.3, 2.4)1.11 (0.67, 1.84

*Adjusted for center, age, sex, background, education, eGFR, and log(UACR)